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Spinocerebellar ataxia type 27 (SCA27) is a very rare subtype of type I autosomal dominant cerebellar ataxia (ADCA type I). It is characterized by early-onset tremor, dyskinesia, and slowly progressive cerebellar ataxia.
Biomarker and diagnostic research for spinocerebellar ataxia type 27 has been reported in the published literature.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
1 clinical trial registered, 1 recruiting. Interventions under study include other interventions. Research is primarily sponsored by academic and government institutions.
19 publications have been identified in PubMed for spinocerebellar ataxia type 27. Research spans Case Report / Case Series (26%), Diagnostic / Biomarker (21%), and Basic Science / Preclinical (21%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 5 | 26% |
Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 6:22 PM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
Testing and diagnosis research |
4 |
21% |
Laboratory research | 4 | 21% |
Disease patterns and progression | 3 | 16% |
Research summaries | 2 | 11% |
Clinical study results | 1 | 5% |
Ransdell JL (2026). [PMID: 41558966](https://pubmed.ncbi.nlm.nih.gov/41558966/). *The Journal of neuroscience : the official journal of the Society for Neuroscience*. [Basic Science / Preclinical]
Gold DR (2026). [PMID: 40693779](https://pubmed.ncbi.nlm.nih.gov/40693779/). *Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society*. [Case Report / Case Series]
Manohar R (2025). [PMID: 40305762](https://pubmed.ncbi.nlm.nih.gov/40305762/). *Brain : a journal of neurology*. [Epidemiology / Natural History]
Tsokkos T (2025). [PMID: 41118032](https://pubmed.ncbi.nlm.nih.gov/41118032/). *Cerebellum (London, England)*. [Case Report / Case Series]
Rettenmaier LA (2025). [PMID: 40679574](https://pubmed.ncbi.nlm.nih.gov/40679574/). *Cerebellum (London, England)*. [Diagnostic / Biomarker]
Conci E (2025). [PMID: 41099962](https://pubmed.ncbi.nlm.nih.gov/41099962/). *Cerebellum (London, England)*. [Case Report / Case Series]
McNames J (2025). [PMID: 41107202](https://pubmed.ncbi.nlm.nih.gov/41107202/). *The Lancet. Digital health*. [Clinical Trial Publication]
Ransdell JL (2025). [PMID: 40323232](https://pubmed.ncbi.nlm.nih.gov/40323232/). *The Journal of general physiology*. [Basic Science / Preclinical]
Rocca C (2025). [PMID: 40004498](https://pubmed.ncbi.nlm.nih.gov/40004498/). *Genes*. [Epidemiology / Natural History]
Novis LE (2025). [PMID: 39920364](https://pubmed.ncbi.nlm.nih.gov/39920364/). *Cerebellum (London, England)*. [Review / Meta-Analysis]
AI-curated news mentioning spinocerebellar ataxia type 27
Updated Mar 14, 2026
A new study provides clinical and genetic insights into pediatric-onset spinocerebellar ataxia type 2, highlighting its rare nature and potential implications for diagnosis and treatment. This research contributes to the understanding of the disease's genetic underpinnings.