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Splenic diffuse red pulp small B-cell lymphoma is a rare, indolent B-cell non-Hodgkin lymphoma characterized by abnormal proliferation of small, monomorphous, basophilic B-lymphocytes, with villous cytoplasm, in the splenic red pulp, bone marrow and peripheral blood. It typically presents in the late clinical stages with splenomegaly and moderate lymphocytosis. Cytopenias are rare and likely associated with hypersplenism.
No clinical trials have been registered for splenic diffuse red pulp small B-cell lymphoma.
14 publications have been identified in PubMed for splenic diffuse red pulp small B-cell lymphoma. Research spans Case Report / Case Series (43%), Review / Meta-Analysis (36%), and Epidemiology / Natural History (14%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 6 | 43% |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 1:59 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Research summaries
5 |
36% |
Disease patterns and progression | 2 | 14% |
Laboratory research | 1 | 7% |
Amiot Q (2026). [PMID: 41395705](https://pubmed.ncbi.nlm.nih.gov/41395705/). *Annales de biologie clinique*. [Review / Meta-Analysis]
Hanna M (2025). [PMID: 40282427](https://pubmed.ncbi.nlm.nih.gov/40282427/). *Genes*. [Case Report / Case Series]
Rocha-Rodrigues B (2025). [PMID: 40220033](https://pubmed.ncbi.nlm.nih.gov/40220033/). *Journal of hematopathology*. [Case Report / Case Series]
Zhang WJ (2025). [PMID: 40921676](https://pubmed.ncbi.nlm.nih.gov/40921676/). *Zhonghua bing li xue za zhi = Chinese journal of pathology*. [Case Report / Case Series]
Lalani A (2025). [PMID: 40585661](https://pubmed.ncbi.nlm.nih.gov/40585661/). *Cureus*. [Case Report / Case Series]
Blombery P (2025). [PMID: 39403047](https://pubmed.ncbi.nlm.nih.gov/39403047/). *Histopathology*. [Epidemiology / Natural History]
Oberic L (2025). [PMID: 40157832](https://pubmed.ncbi.nlm.nih.gov/40157832/). *Bulletin du cancer*. [Case Report / Case Series]
N LN (2025). [PMID: 40796473](https://pubmed.ncbi.nlm.nih.gov/40796473/). *Clinical lymphoma, myeloma & leukemia*. [Epidemiology / Natural History]
Troussard X (2024). [PMID: 38440808](https://pubmed.ncbi.nlm.nih.gov/38440808/). *American journal of hematology*. [Review / Meta-Analysis]
Troussard X (2024). [PMID: 39535173](https://pubmed.ncbi.nlm.nih.gov/39535173/). *Expert review of hematology*. [Review / Meta-Analysis]