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staphylococcal necrotizing pneumonia - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

staphylococcal necrotizing pneumonia

MONDO:0018183

Overview

Staphylococcal necrotizing pneumonia is a rare, bacterial, pulmonary infectious disease, caused by a Panton-Valentine leukocidin-producing Staphylococcus aureus strain, characterized by severe respiratory failure, extensive, rapidly progressing pneumonia and hemorrhagic lung necrosis. Patients typically present with influenza-like symptoms, such as fever, cough, and chest pain, as well as hemoptysis, hypotension, leukopenia, and severe respiratory symptoms that rapidly evolve to acute respiratory distress syndrome and septic shock. High mortality is associated.

ResearchLimited published research (4 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Fever, Elevated white blood cell count (increased total leukocyte count), Pneumonia, and Dyspnea and others; and common findings: Low blood oxygen levels (hypoxemia), Nonproductive cough, Bacteremia, and Parenchymal consolidation and others. 38 total HPO annotations.

Organ System	Phenotype Count	Example Features
Lungs and breathing	11	Low blood oxygen levels (hypoxemia), Pneumothorax, Pulmonary infiltrates

Diagnosis

Biomarker and diagnostic research for staphylococcal necrotizing pneumonia has been reported in the published literature.

Prognosis

Phenotype severity distribution: 9 very common features, 13 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for staphylococcal necrotizing pneumonia.

4 publications have been identified in PubMed for staphylococcal necrotizing pneumonia. Research spans Diagnostic / Biomarker (25%), Review / Meta-Analysis (25%), and Basic Science / Preclinical (25%).

Recent Publications

Di Bella S (2025). [PMID: 40323347](https://pubmed.ncbi.nlm.nih.gov/40323347/). *European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology*. [Review / Meta-Analysis]
Camaione S (2025). [PMID: 40448417](https://pubmed.ncbi.nlm.nih.gov/40448417/). *FASEB journal : official publication of the Federation of American Societies for Experimental Biology*. [Basic Science / Preclinical]
Nakaminami H (2025). [PMID: 40024689](https://pubmed.ncbi.nlm.nih.gov/40024689/). *Biological & pharmaceutical bulletin*. [Epidemiology / Natural History]
Müller E (2025). [PMID: 40137723](https://pubmed.ncbi.nlm.nih.gov/40137723/). *Pathogens (Basel, Switzerland)*. [Diagnostic / Biomarker]

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 11:11 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:36238

GARD

Genetic and Rare Diseases Info Center

GARD:18821

Questions for Your Care Team

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Kisho

staphylococcal necrotizing pneumonia

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Latest News & Developments

Surgical Management of Necrotizing Pneumonia in Pediatric Patients. A Retrospective Analysis in a Third-Level Center.

staphylococcal necrotizing pneumonia

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Latest News & Developments

Surgical Management of Necrotizing Pneumonia in Pediatric Patients. A Retrospective Analysis in a Third-Level Center.