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stromal keratitis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

stromal keratitis

MONDO:0015291

Find Clinical TrialsTrials

Overview

Herpes simplex (HSV) stromal keratitis is an infectious ocular disease of either necrotizing or non-necrotizing form, due to an HSV infection, and characterized by corneal stromal necrosis, inflammation, ulceration and infiltration by leukocytes. Corneal perforation and blindness can also occur in severe cases.

Clinical Trials2 registered · 1 recruiting

Diagnosis

Biomarker and diagnostic research for stromal keratitis has been reported in the published literature.

Prognosis

Estimated prevalence: 1-9 in 100,000 (Uncommon).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

2 clinical trials registered, 1 recruiting. Interventions under study include drug therapy and gene therapy. Pipeline includes 1 PHASE2, 1 PHASE1. Research is primarily industry-sponsored.

54 publications have been identified in PubMed for stromal keratitis. Research spans Review / Meta-Analysis (28%), Basic Science / Preclinical (26%), and Case Report / Case Series (17%).

Research Type	Count	% of Total
Research summaries	15	28%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 9:38 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:137599

GARD

Genetic and Rare Diseases Info Center

GARD:19879

Questions for Your Care Team

→Are any of the 2 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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stromal keratitis

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications