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superior mesenteric artery syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

superior mesenteric artery syndrome

MONDO:0002687

Also known as:superior mesenteric artery syndromic diseasesyndromic disease of superior mesenteric arteryArteriomesenteric duodenal compression syndrome

Find Clinical TrialsTrials

Overview

Superior mesenteric artery syndrome (SMAS) is a digestive condition that occurs when the duodenum (the first part of the small intestine) is compressed between two arteries (the aorta and the superior mesenteric artery). This compression causes partial or complete blockage of the duodenum. Symptoms vary based on severity, but can be severely debilitating. Symptoms may include abdominal pain, fullness, nausea, vomiting, and/or weight loss. SMAS typically is due toloss of the mesenteric fat pad (fatty tissue that surrounds the superior mesenteric artery). The most common cause is significant weight loss caused by medical disorders, psychological disorders, or surgery. In younger patients, it most commonly occurs after corrective spinal surgery for scoliosis. Delays in diagnosis may result in significant complications. Depending on the cause and severity, treatment options may include addressing the underlying cause, dietary changes (small feedings or a liquid diet), and/or surgery. Symptoms may not resolve completely after treatment.

Clinical Trials2 registered · 2 recruiting

Patient Orgs1 organizations · Superior Mesenteric Artery Syndrome Research Awareness And Support

Diagnosis

Biomarker and diagnostic research for superior mesenteric artery syndrome has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

2 clinical trials registered, 2 recruiting. Interventions under study include other interventions and medical devices. Pipeline includes 1 NA. Research is sponsored by a mix of industry and academic institutions.

166 publications have been identified in PubMed for superior mesenteric artery syndrome. Research spans Case Report / Case Series (77%), Review / Meta-Analysis (11%), and Clinical Trial Publication (4%).

Research Type	Count	% of Total
Patient case studies	116

Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 8:33 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Patient Support

Patient Advocacy Groups

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Superior Mesenteric Artery Syndrome Research Awareness And SupportPrimary Focus

Patient Advocacy Groups (PAGs) provide support, resources, and community for patients and caregivers.

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Medical References

External Resources

Orphanet

European rare disease database

Orphanet:622099

GARD

Genetic and Rare Diseases Info Center

GARD:7712

Questions for Your Care Team

→Are any of the 2 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→How can I connect with Superior Mesenteric Artery Syndrome Research Awareness And Support and other patient organizations for support?

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Kisho

superior mesenteric artery syndrome

Overview

Diagnosis

Research Landscape

Patient Support

Patient Advocacy Groups

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Superior mesenteric artery aneurysm associated with chronic mesenteric ischemia in absence of identifiable risk factors and review of current literature.

superior mesenteric artery syndrome

Overview

Diagnosis

Research Landscape

Patient Support

Patient Advocacy Groups

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Superior mesenteric artery aneurysm associated with chronic mesenteric ischemia in absence of identifiable risk factors and review of current literature.