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thoracic outlet syndrome (TOS) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

thoracic outlet syndrome

MONDO:0005979

Also known as:TOSTOS - thoracic outlet syndromethoracic outlet compression syndrome

Find Clinical TrialsTrials

Overview

A syndrome resulting from the compression of the blood vessels or nerves in the space between the clavicle and first rib (thoracic outlet). It is caused by car accident injuries or repetitive job or sport-related injuries. Signs and symptoms include pain in the shoulders and neck, numbness in the fingers, and weakening grip.

Clinical Trials9 registered · 2 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Paresthesia; and common findings: Abnormal rib morphology, Edema, Muscle weakness, and Arthralgia and others. 11 total HPO annotations.

Organ System	Phenotype Count	Example Features
Muscles	3	Muscle weakness, Myalgia, Muscle spasm

Diagnosis

Biomarker and diagnostic research for thoracic outlet syndrome has been reported in the published literature.

Prognosis

Phenotype severity distribution: 1 very common feature, 5 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

9 clinical trials registered, 2 recruiting. Interventions under study include other interventions, medical devices, and drug therapy. Pipeline includes 1 PHASE4, 5 NA. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT06992752](https://clinicaltrials.gov/study/NCT06992752)

Data assembled from 5 of 12 sources · Last updated Sep 18, 2026, 8:30 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:97330

GARD

Genetic and Rare Diseases Info Center

GARD:7759

Questions for Your Care Team

→Are any of the 9 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Research summaries	23	42%
Clinical study results	14	25%
Patient case studies	8	15%
Other research	4	7%
Disease patterns and progression	4	7%
Testing and diagnosis research	2	4%

Kisho

thoracic outlet syndrome

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

thoracic outlet syndrome

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications