NONO encodes non-POU domain containing octamer binding (471 aa). DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Highest expression in Cells EBV-transformed lymphocytes (238.9 TPM) and Ovary (222.1 TPM).

Syndromic X-linked intellectual disability 34 is associated with mutations in the NONO gene on chromosome X.

NONO is classified as a druggable target (Clinically Actionable, Dna Repair, and Transcription Factor categories) with score 0.0.

Genetic testing for NONO is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for syndromic X-linked intellectual disability 34 has been reported in the published literature.

Phenotype severity distribution: 36 always present features, 21 common features.

Estimated prevalence: <1 in 1,000,000 (VERY_RARE).

No clinical trials have been registered for syndromic X-linked intellectual disability 34.

36 publications have been identified in PubMed for syndromic X-linked intellectual disability 34. Research spans Basic Science / Preclinical (31%), Case Report / Case Series (23%), and Diagnostic / Biomarker (14%).

Recent Publications

• Kaler SG (2026). [PMID: 41687279](https://pubmed.ncbi.nlm.nih.gov/41687279/). *Mol Genet Metab*. [Diagnostic / Biomarker]

• Huang R (2026). [PMID: 41205496](https://pubmed.ncbi.nlm.nih.gov/41205496/). *Eur J Obstet Gynecol Reprod Biol*. [Case Report / Case Series]

• Zhang Y (2026). [PMID: 41727761](https://pubmed.ncbi.nlm.nih.gov/41727761/). *Front Pediatr*. [Case Report / Case Series]

• Zhao Y (2026). [PMID: 41705901](https://pubmed.ncbi.nlm.nih.gov/41705901/). *Prenat Diagn*. [Basic Science / Preclinical]

• Miller JS (2026). [PMID: 41260060](https://pubmed.ncbi.nlm.nih.gov/41260060/). *Pediatr Neurol*. [Epidemiology / Natural History]

• Tkemladze T (2026). [PMID: 41044236](https://pubmed.ncbi.nlm.nih.gov/41044236/). *Eur J Hum Genet*. [Diagnostic / Biomarker]

• Duan H (2026). [PMID: 42244324](https://pubmed.ncbi.nlm.nih.gov/42244324/). *Zhong Nan Da Xue Xue Bao Yi Xue Ban*. [Review / Meta-Analysis]

• Ta D (2026). [PMID: 41535863](https://pubmed.ncbi.nlm.nih.gov/41535863/). *Orphanet J Rare Dis*. [Diagnostic / Biomarker]

• Proteau-Lemieux M (2026). [PMID: 41657078](https://pubmed.ncbi.nlm.nih.gov/41657078/). *Autism Res*. [Basic Science / Preclinical]

• Planté-Bordeneuve P (2025). [PMID: 39709004](https://pubmed.ncbi.nlm.nih.gov/39709004/). *Eur J Med Genet*. [Case Report / Case Series]