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A benign adnexal neoplasm occurring during childhood or adolescence. It usually presents as a papular lesion or a plaque on the head and neck. It may arise in an organoid nevus such as sebaceous. It is characterized by an endophytic invagination of the epithelium into the dermis. There are dermal cystic spaces present, containing villous projections. Complete excision is curative.
Estimated prevalence: <1 in 1,000,000 (VERY_RARE).
No clinical trials have been registered for syringocystadenoma papilliferum.
29 publications have been identified in PubMed for syringocystadenoma papilliferum. Research spans Case Report / Case Series (70%), Other (7%), and Review / Meta-Analysis (7%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 19 | 70% |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 8:41 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
2 |
7% |
Research summaries | 2 | 7% |
Laboratory research | 2 | 7% |
Clinical study results | 1 | 4% |
Disease patterns and progression | 1 | 4% |
Rooper LM (2026). [PMID: 41266927](https://pubmed.ncbi.nlm.nih.gov/41266927/). *Virchows Arch*. [Basic Science / Preclinical]
Homsi HA (2026). [PMID: 41979430](https://pubmed.ncbi.nlm.nih.gov/41979430/). *J Cutan Pathol*. [Case Report / Case Series]
Costa MB (2026). [PMID: 41672955](https://pubmed.ncbi.nlm.nih.gov/41672955/). *Pediatr Dermatol*. [Case Report / Case Series]
Malone GE (2026). [PMID: 41392389](https://pubmed.ncbi.nlm.nih.gov/41392389/). *J Cutan Pathol*. [Case Report / Case Series]
Ihrler S (2026). [PMID: 41572003](https://pubmed.ncbi.nlm.nih.gov/41572003/). *Virchows Arch*. [Basic Science / Preclinical]
Troupi M (2025). [PMID: 40951014](https://pubmed.ncbi.nlm.nih.gov/40951014/). *Cureus*. [Case Report / Case Series]
Robles-Silva C (2025). [PMID: 41166780](https://pubmed.ncbi.nlm.nih.gov/41166780/). *An Bras Dermatol*. [Case Report / Case Series]
Han B (2025). [PMID: 39152863](https://pubmed.ncbi.nlm.nih.gov/39152863/). *Indian J Dermatol Venereol Leprol*. [Other]
Farrell LC (2025). [PMID: 41418291](https://pubmed.ncbi.nlm.nih.gov/41418291/). *Ophthalmic Plast Reconstr Surg*. [Case Report / Case Series]
Zhou W (2025). [PMID: 40928198](https://pubmed.ncbi.nlm.nih.gov/40928198/). *J Dermatol*. [Epidemiology / Natural History]