Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy
Any systemic lupus erythematosus in which the cause of the disease is a variation in the TLR7 gene.
Features include always present findings: Antinuclear antibody positivity; and common findings: Alopecia, Malar rash, Anxiety, and Decreased total lymphocyte count and others.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Skin | 3 | Alopecia, Malar rash, Systemic lupus erythematosus |
TLR7 function has not been fully characterized.
Systemic lupus erythematosus 17 has been associated with mutations in the TLR7 gene on chromosome X.
Genetic testing for TLR7 is available. Testing is considered supportive for diagnosis.
Biomarker and diagnostic research for systemic lupus erythematosus 17 has been reported in the published literature.
Phenotype severity distribution: 1 always present feature, 22 common features.
No clinical trials have been registered for systemic lupus erythematosus 17.
208 publications have been identified in PubMed for systemic lupus erythematosus 17. Kisho has analyzed 58 by research type. Research spans Basic Science / Preclinical (34%), Clinical Trial Publication (19%), and Epidemiology / Natural History (17%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 20 | 34% |
Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 1:55 PM UTC
Online Mendelian Inheritance in Man
3 |
Anxiety, Headache, Chorea |
Blood and immune system | 3 | Low white blood cell count (decreased total leukocyte count), Autoimmune thrombocytopenia, Low platelet count (thrombocytopenia) |
Lab test results | 2 | Antinuclear antibody positivity, Anti-aquaporin 4 antibody positivity |
Metabolism | 2 | Fever, Recurrent fever |
Heart and blood vessels | 2 | Hypertensive crisis, Mitral regurgitation |
Eyes | 1 | Optic neuritis |
Bones and joints | 1 | Arthralgia |
Clinical study results |
11 |
19% |
Disease patterns and progression | 10 | 17% |
Research summaries | 9 | 16% |
New treatment approaches | 4 | 7% |
Patient case studies | 2 | 3% |
Other research | 1 | 2% |
Testing and diagnosis research | 1 | 2% |
Tusseau M (2026). [PMID: 41930824](https://pubmed.ncbi.nlm.nih.gov/41930824/). *EBioMedicine*. [Basic Science / Preclinical]
Hua M (2026). [PMID: 42112348](https://pubmed.ncbi.nlm.nih.gov/42112348/). *Front Immunol*. [Review / Meta-Analysis]
Beretta L (2026). [PMID: 41570368](https://pubmed.ncbi.nlm.nih.gov/41570368/). *J Autoimmun*. [Basic Science / Preclinical]
Gao J (2026). [PMID: 41240964](https://pubmed.ncbi.nlm.nih.gov/41240964/). *Lancet*. [Clinical Trial Publication]
Zheng S (2025). [PMID: 40585331](https://pubmed.ncbi.nlm.nih.gov/40585331/). *PeerJ*. [Basic Science / Preclinical]
Ramírez-Lara E (2025). [PMID: 40829709](https://pubmed.ncbi.nlm.nih.gov/40829709/). *Autoimmun Rev*. [Review / Meta-Analysis]
Depascale R (2025). [PMID: 40244828](https://pubmed.ncbi.nlm.nih.gov/40244828/). *Rheumatology (Oxford)*. [Clinical Trial Publication]
Osborne GA (2025). [PMID: 41442501](https://pubmed.ncbi.nlm.nih.gov/41442501/). *Sci Transl Med*. [Basic Science / Preclinical]
Fang QY (2025). [PMID: 40133904](https://pubmed.ncbi.nlm.nih.gov/40133904/). *BMC Pregnancy Childbirth*. [Basic Science / Preclinical]
Jin HZ (2025). [PMID: 39680262](https://pubmed.ncbi.nlm.nih.gov/39680262/). *Clin Rheumatol*. [Epidemiology / Natural History]