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A malignant disease of the T-lymphocytes in the bone marrow, thymus, and/or blood.
Biomarker and diagnostic research for T-cell leukemia has been reported in the published literature.
22 clinical trials registered, 15 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and biologic therapy. Pipeline includes 8 PHASE2, 6 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT01137825](https://clinicaltrials.gov/study/NCT01137825) |
Data assembled from 3 of 12 sources · Last updated Nov 2, 2026, 2:57 AM UTC
Common questions about T-cell leukemia
Registry of Older Patients With Cancer |
— |
UNC Lineberger Comprehensive Cancer Center |
RECRUITING |
[NCT05031897](https://clinicaltrials.gov/study/NCT05031897) | Two Step Haplo With Radiation Conditioning | PHASE2 | Thomas Jefferson University | RECRUITING |
[NCT07159620](https://clinicaltrials.gov/study/NCT07159620) | Venetoclax Combined With Azacitidine, Chidamide, Vindesine, and Dexamethasone in Newly Diagnosed ETP-ALL Like Patients | PHASE2 | The First Affiliated Hospital of Soochow University | RECRUITING |
[NCT07356245](https://clinicaltrials.gov/study/NCT07356245) | Ruxolitinib Maintenance Post-Hematopoietic Stem Cell Transplant T-Cell Lymphoma | PHASE2 | Ohio State University Comprehensive Cancer Center | RECRUITING |
[NCT03829540](https://clinicaltrials.gov/study/NCT03829540) | CD4CAR for CD4+ Leukemia and Lymphoma | PHASE1 | Huda Salman | RECRUITING |
230 publications have been identified in PubMed for T-cell leukemia. Research spans Review / Meta-Analysis (35%), Basic Science / Preclinical (33%), and Clinical Trial Publication (12%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 81 | 35% |
Laboratory research | 77 | 33% |
Clinical study results | 28 | 12% |
New treatment approaches | 24 | 10% |
Disease patterns and progression | 8 | 3% |
Testing and diagnosis research | 6 | 3% |
Other research | 3 | 1% |
Patient case studies | 3 | 1% |
Toyama K (2026). [PMID: 41605696](https://pubmed.ncbi.nlm.nih.gov/41605696/). *J Clin Exp Hematop*. [Basic Science / Preclinical]
Penter L (2026). [PMID: 41026928](https://pubmed.ncbi.nlm.nih.gov/41026928/). *Blood*. [Basic Science / Preclinical]
Itoh-Nakadai A (2026). [PMID: 41587986](https://pubmed.ncbi.nlm.nih.gov/41587986/). *Nat Commun*. [Gene Therapy / Novel Therapeutics]
Fetsch V (2026). [PMID: 41144759](https://pubmed.ncbi.nlm.nih.gov/41144759/). *Blood*. [Basic Science / Preclinical]
Torrent A (2026). [PMID: 40555197](https://pubmed.ncbi.nlm.nih.gov/40555197/). *Acta haematologica*. [Review / Meta-Analysis]
Wahnschaffe L (2026). [PMID: 41803141](https://pubmed.ncbi.nlm.nih.gov/41803141/). *Nat Commun*. [Basic Science / Preclinical]
Li F (2026). [PMID: 41806835](https://pubmed.ncbi.nlm.nih.gov/41806835/). *Cell*. [Gene Therapy / Novel Therapeutics]
Zhu Y (2026). [PMID: 41727472](https://pubmed.ncbi.nlm.nih.gov/41727472/). *Front Immunol*. [Review / Meta-Analysis]
Pinheiro PS (2026). [PMID: 42060270](https://pubmed.ncbi.nlm.nih.gov/42060270/). *JAMA Oncol*. [Diagnostic / Biomarker]
Guégan M (2026). [PMID: 41510799](https://pubmed.ncbi.nlm.nih.gov/41510799/). *Expert Rev Hematol*. [Review / Meta-Analysis]
AI-curated news mentioning T-cell leukemia
Updated Oct 16, 2026
A study published in PubMed explores the use of T-cell receptor β-chain constant region 1/2 skewing as a potential surrogate marker for clonality in cells infected with human T-cell leukemia virus type 1. This research could enhance understanding of T-cell leukemia and its progression.