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temporomandibular joint dysfunction syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

temporomandibular joint dysfunction syndrome

MONDO:0021895

Also known as:Costen SyndromeCosten's SyndromeCosten's complex

Find Clinical TrialsTrials

Overview

A common disorder noted with jaw movement. It may be caused by malocclusion, repetitive use injury, trauma or arthritis. It is more prevalent among females between their second and fourth decades. Clinical signs include preauricular pain, temporomandibular joint clicking (as the mandibular condyle slips from the articulation made with the capsular disk and temporal bone) and restriction of jaw motion. Clinical course is typically benign but may progress to associated headaches, ear and neck pain, tinnitus and dislocation of temporomandibular joint. Prognosis is favorable as a majority of cases will respond to conservative management.

Clinical Trials47 registered · 11 recruiting

Diagnosis

Biomarker and diagnostic research for temporomandibular joint dysfunction syndrome has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

47 clinical trials registered, 11 recruiting. Interventions under study include other interventions, medical devices, drug therapy, and procedural interventions. Pipeline includes 1 PHASE4, 1 PHASE2, 1 PHASE1. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT07474662](https://clinicaltrials.gov/study/NCT07474662)

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 11:12 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

Questions for Your Care Team

→Are any of the 47 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Disease patterns and progression	20	30%
Clinical study results	17	26%
Research summaries	14	21%
Testing and diagnosis research	6	9%
Patient case studies	5	8%
Laboratory research	3	5%
New treatment approaches	1	2%

Kisho

temporomandibular joint dysfunction syndrome

Overview

Diagnosis

Research Landscape

Medical References

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Traumatic Intracranial Displacement of an Intact Temporomandibular Joint Condyle: A Case Report and Literature Review.

temporomandibular joint dysfunction syndrome

Overview

Diagnosis

Research Landscape

Medical References

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Traumatic Intracranial Displacement of an Intact Temporomandibular Joint Condyle: A Case Report and Literature Review.