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testicular germ cell tumor (TGCT) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

testicular germ cell tumor

MONDO:0010108

Also known as:TGCTgerm cell neoplasm of testisgerm cell neoplasm of the testis

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Overview

A germ cell tumor arising from the testis. Representative examples include teratoma, seminoma, embryonal carcinoma, and yolk sac tumor.

GeneticsMultifactorial, Sporadic (not inherited) · 2 genes (KIT, STK11)

Clinical Trials10 registered · 5 recruiting

Clinical Presentation

Features include: Teratoma, Choriocarcinoma, Elevated circulating alpha-fetoprotein concentration, and Embryonal neoplasm and 1 more.

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Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

10 clinical trials registered, 5 recruiting. Interventions under study include other interventions, procedural interventions, drug therapy, and biologic therapy. Pipeline includes 2 PHASE1, 3 NA. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT06276491](https://clinicaltrials.gov/study/NCT06276491)	Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors	PHASE1	Xencor, Inc.	RECRUITING
[NCT07453082](https://clinicaltrials.gov/study/NCT07453082)	A Prospective Study to Evaluate miRNA371 and Outcomes in Patients With Newly Diagnosed Germ Cell Tumors	—	Fondazione del Piemonte per l'Oncologia	RECRUITING
[NCT06060873](https://clinicaltrials.gov/study/NCT06060873)	MAGESTIC Trial: MiRNA in Detecting Active Germ Cell Tumors in Early Suspected and MetastaTIC Disease Trial	—	University of Southern California	RECRUITING
[NCT05670938](https://clinicaltrials.gov/study/NCT05670938)	Follow-up After Surgery for Testicular Cancer	—	Erasmus Medical Center	RECRUITING
[NCT07777887](https://clinicaltrials.gov/study/NCT07777887)	Sentinel Node Identification Using Gamma and Near-Infrared Imaging in TesticulAr MaLignancies	—	N.N. Petrov National Medical Research Center of Oncology	RECRUITING

203 publications have been identified in PubMed for testicular germ cell tumor. Research spans Basic Science / Preclinical (28%), Review / Meta-Analysis (19%), and Epidemiology / Natural History (19%).

Research Type	Count	% of Total
Laboratory research	50	28%
Research summaries	35	19%
Disease patterns and progression	34	19%
Testing and diagnosis research	20	11%
Patient case studies	17	9%
Clinical study results	14

Recent Publications

Bremmer F (2026). [PMID: 41384704](https://pubmed.ncbi.nlm.nih.gov/41384704/). *Histopathology*. [Review / Meta-Analysis]
Tekinaslan H (2026). [PMID: 40944935](https://pubmed.ncbi.nlm.nih.gov/40944935/). *Urol Int*. [Diagnostic / Biomarker]
Conduit C (2026). [PMID: 41835342](https://pubmed.ncbi.nlm.nih.gov/41835342/). *Ther Adv Med Oncol*. [Epidemiology / Natural History]
Liu G (2026). [PMID: 42131333](https://pubmed.ncbi.nlm.nih.gov/42131333/). *Front Immunol*. [Diagnostic / Biomarker]
Choi S (2026). [PMID: 41674621](https://pubmed.ncbi.nlm.nih.gov/41674621/). *medRxiv*. [Basic Science / Preclinical]
Chen S (2026). [PMID: 41593694](https://pubmed.ncbi.nlm.nih.gov/41593694/). *Diagnostic pathology*. [Diagnostic / Biomarker]
Islam R (2026). [PMID: 41773555](https://pubmed.ncbi.nlm.nih.gov/41773555/). *Andrology*. [Review / Meta-Analysis]
Oliveira-Lopes B (2026). [PMID: 41128509](https://pubmed.ncbi.nlm.nih.gov/41128509/). *Current opinion in urology*. [Review / Meta-Analysis]
Alfano M (2026). [PMID: 40658795](https://pubmed.ncbi.nlm.nih.gov/40658795/). *The Journal of clinical endocrinology and metabolism*. [Gene Therapy / Novel Therapeutics]
Bowling GC (2026). [PMID: 41687980](https://pubmed.ncbi.nlm.nih.gov/41687980/). *Gene*. [Case Report / Case Series]

Kisho

testicular germ cell tumor

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

KIT

STK11

Diagnosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Latest News & Developments

A Case of a Rare Testicular Tumor With Synchronous Malignancy.

Risk factors and causes of early death in germ cell tumors: a Global Society for Rare GU tumors study.

Treatment options in platinum-refractory male germ cell cancers: current standards and future directions.

testicular germ cell tumor

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

KIT

STK11

Diagnosis

Research Landscape

Recent Publications

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Latest News & Developments

A Case of a Rare Testicular Tumor With Synchronous Malignancy.

Risk factors and causes of early death in germ cell tumors: a Global Society for Rare GU tumors study.

Treatment options in platinum-refractory male germ cell cancers: current standards and future directions.