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thyroid cancer, nonmedullary, 4 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

thyroid cancer, nonmedullary, 4

MONDO:0014681

Also known as:FOXE1 thyroid cancer, nonmedullarythyroid cancer, nonmedullary caused by mutation in FOXE1thyroid cancer, nonmedullary, type 4

Overview

Any thyroid cancer, nonmedullary in which the cause of the disease is a mutation in the FOXE1 gene.

GeneticsAutosomal dominant

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include common findings: Papillary thyroid carcinoma; and sometimes findings: Ovarian neoplasm, Basal cell carcinoma, and Prostate cancer. 5 total HPO annotations.

Organ System	Phenotype Count	Example Features
Hormones	1	Papillary thyroid carcinoma

Explore clinical features

Diagnosis

Biomarker and diagnostic research for thyroid cancer, nonmedullary, 4 has been reported in the published literature.

Prognosis

Phenotype severity distribution: 1 common feature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for thyroid cancer, nonmedullary, 4.

272 publications have been identified in PubMed for thyroid cancer, nonmedullary, 4. Research spans Epidemiology / Natural History (28%), Basic Science / Preclinical (26%), and Clinical Trial Publication (18%).

Research Type	Count	% of Total
Disease patterns and progression	63	28%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 12:51 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:616534

GARD

Genetic and Rare Diseases Info Center

GARD:16132

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
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thyroid cancer, nonmedullary, 4

Overview

Clinical Presentation

Explore clinical features

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

GARD

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Questions for Your Care Team

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