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tropical spastic paraparesis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

tropical spastic paraparesis

MONDO:0008039

Also known as:HAM/TSPHTLV-1-associated myelopathy/tropical spastic paraparesisHTLV-associated myelopathy

Find Clinical TrialsTrials

Overview

Tropical spastic paraparesis is a chronic systemic immune-mediated inflammatory myeloneuropathy, more frequently reported in women than in men, that usually presents in adulthood with slowly progressive spastic paraparesis of the lower limbs, bladder and bowel dysfunction, and sensory disturbances in the lower extremities (e.g. paresthesia and dysesthesia) and that is associated with a human T-cell lymphotropic virus type 1 (HTLV-1) infection.

Clinical Trials2 registered · 2 recruiting

Clinical Presentation

Features include: Myelopathy, Abnormal pyramidal sign, and Spastic paraparesis.

Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 6:54 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:159580

Orphanet

European rare disease database

Orphanet:289326

GARD

Genetic and Rare Diseases Info Center

GARD:8208

Questions for Your Care Team

→Are any of the 2 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

2 clinical trials registered, 2 recruiting. Interventions under study include drug therapy and other interventions. Pipeline includes 1 PHASE1. Research is primarily sponsored by academic and government institutions.

118 publications have been identified in PubMed for tropical spastic paraparesis. Research spans Basic Science / Preclinical (31%), Review / Meta-Analysis (26%), and Epidemiology / Natural History (17%).

Research Type	Count	% of Total
Laboratory research	37	31%
Research summaries	31	26%
Disease patterns and progression	20	17%
Testing and diagnosis research	9	8%
Patient case studies	9	8%
Clinical study results	6	5%
New treatment approaches	4	3%
Other research	2	2%

Recent Publications

Siyadat P (2026). [PMID: 42246505](https://pubmed.ncbi.nlm.nih.gov/42246505/). *J Med Virol*. [Basic Science / Preclinical]
Prakash R (2026). [PMID: 41760966](https://pubmed.ncbi.nlm.nih.gov/41760966/). *Neurol Sci*. [Case Report / Case Series]
Morrison AA (2026). [PMID: 41894649](https://pubmed.ncbi.nlm.nih.gov/41894649/). *Neurol Neuroimmunol Neuroinflamm*. [Review / Meta-Analysis]
Neves ES (2026). [PMID: 41717922](https://pubmed.ncbi.nlm.nih.gov/41717922/). *J Med Virol*. [Epidemiology / Natural History]
Noori B (2026). [PMID: 41737026](https://pubmed.ncbi.nlm.nih.gov/41737026/). *Can J Infect Dis Med Microbiol*. [Review / Meta-Analysis]
Letafati A (2026). [PMID: 41714539](https://pubmed.ncbi.nlm.nih.gov/41714539/). *J Neurovirol*. [Review / Meta-Analysis]
Fernandes LA (2026). [PMID: 41751961](https://pubmed.ncbi.nlm.nih.gov/41751961/). *Int J Mol Sci*. [Basic Science / Preclinical]
Kamate DP (2026). [PMID: 42031371](https://pubmed.ncbi.nlm.nih.gov/42031371/). *BMJ Case Rep*. [Case Report / Case Series]
Blanco S (2026). [PMID: 41242568](https://pubmed.ncbi.nlm.nih.gov/41242568/). *Microb Pathog*. [Epidemiology / Natural History]
Forouzanfar ES (2026). [PMID: 32809660](https://pubmed.ncbi.nlm.nih.gov/32809660/). *Unknown Journal*. [Basic Science / Preclinical]

Kisho

tropical spastic paraparesis

Overview

Clinical Presentation

Medical References

External Resources

OMIM

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Diagnosis

Prognosis

Research Landscape

Recent Publications

Latest News & Developments

Ovarian Lymphoma and Bone Metastasis Presenting With Paraparesis in an Adolescent: A Case Report.

Acute myocardial infarction in a patient with HAM/TSP evaluated for circulatory dynamics during mobilization before and after antihypertensive drug modification: a case report.

Use of the 10-meter timed walk for monitoring long-term gait progression in human T-cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis: a 10-year analysis from the Japanese HAM-net registry.

tropical spastic paraparesis

Overview

Clinical Presentation

Medical References

External Resources

OMIM

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Diagnosis

Prognosis

Research Landscape

Recent Publications

Latest News & Developments

Ovarian Lymphoma and Bone Metastasis Presenting With Paraparesis in an Adolescent: A Case Report.

Acute myocardial infarction in a patient with HAM/TSP evaluated for circulatory dynamics during mobilization before and after antihypertensive drug modification: a case report.

Use of the 10-meter timed walk for monitoring long-term gait progression in human T-cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis: a 10-year analysis from the Japanese HAM-net registry.