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An infectious process that affects the brain and/or spinal cord. Representative examples include encephalitis, poliomyelitis, arachnoiditis, and meningitis.
Biomarker and diagnostic research for central nervous system infectious disorder has been reported in the published literature.
9 clinical trials registered, 4 recruiting. Interventions under study include other interventions, drug therapy, and procedural interventions. Pipeline includes 3 NA. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06418048](https://clinicaltrials.gov/study/NCT06418048) |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 12:50 AM UTC
INfectious DIsease REgistry BIObank
— |
IRCCS San Raffaele |
RECRUITING |
[NCT06412549](https://clinicaltrials.gov/study/NCT06412549) | Effect of a Bundle of Interventions on the Outcomes of Patients With Intracranial Devices (ICP Monitor e EVD) | NA | Beneficência Portuguesa de São Paulo | NOT_YET_RECRUITING |
[NCT06704997](https://clinicaltrials.gov/study/NCT06704997) | Machine Learning to Predict Factors Affecting Rehabilitation Length of Stay and Healthcare Costs for Neurological Rehabilitation | — | Tan Tock Seng Hospital | ACTIVE_NOT_RECRUITING |
[NCT07435649](https://clinicaltrials.gov/study/NCT07435649) | Investigation of the Delve Detect Cerebrospinal Fluid (CSF) Metagenomic Next-generation Sequencing (mNGS) Test When Used for the Initial Diagnostic Workup of Patients With Suspected Central Nervous System (CNS) Infection | NA | Delve Bio, Inc. | RECRUITING |
[NCT06358209](https://clinicaltrials.gov/study/NCT06358209) | Safety and Efficacy of Ventricular Irrigation for Ventriculitis | NA | RenJi Hospital | RECRUITING |
275 publications have been identified in PubMed for central nervous system infectious disorder. Kisho has analyzed 218 by research type. Research spans Review / Meta-Analysis (39%), Epidemiology / Natural History (14%), and Case Report / Case Series (13%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 86 | 39% |
Disease patterns and progression | 31 | 14% |
Patient case studies | 28 | 13% |
Laboratory research | 28 | 13% |
Testing and diagnosis research | 25 | 11% |
Clinical study results | 13 | 6% |
Other research | 5 | 2% |
New treatment approaches | 2 | 1% |
Alvarez Mulett S (2026). [PMID: 40668900](https://pubmed.ncbi.nlm.nih.gov/40668900/). *Clin Infect Dis*. [Clinical Trial Publication]
Moutombi Ditombi BC (2026). [PMID: 41546100](https://pubmed.ncbi.nlm.nih.gov/41546100/). *AIDS Res Ther*. [Epidemiology / Natural History]
Kara TT (2026). [PMID: 41840269](https://pubmed.ncbi.nlm.nih.gov/41840269/). *Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery*. [Clinical Trial Publication]
Hoellinger B (2026). [PMID: 41242395](https://pubmed.ncbi.nlm.nih.gov/41242395/). *Infect Dis Now*. [Review / Meta-Analysis]
Chowdhury S (2026). [PMID: 40730474](https://pubmed.ncbi.nlm.nih.gov/40730474/). *Pract Neurol*. [Case Report / Case Series]
Schmidt-Hieber M (2026). [PMID: 41783087](https://pubmed.ncbi.nlm.nih.gov/41783087/). *EClinicalMedicine*. [Clinical Trial Publication]
Zhang G (2026). [PMID: 41780885](https://pubmed.ncbi.nlm.nih.gov/41780885/). *J Pharm Sci*. [Gene Therapy / Novel Therapeutics]
de La Porte C (2026). [PMID: 41432290](https://pubmed.ncbi.nlm.nih.gov/41432290/). *Medical mycology*. [Diagnostic / Biomarker]
Li K (2026). [PMID: 41667472](https://pubmed.ncbi.nlm.nih.gov/41667472/). *Nature communications*. [Basic Science / Preclinical]
Luque Paz D (2026). [PMID: 40392145](https://pubmed.ncbi.nlm.nih.gov/40392145/). *Brain : a journal of neurology*. [Epidemiology / Natural History]
AI-curated news mentioning central nervous system infectious disorder
Updated Sep 7, 2026
A study explores the use of intrathecal and systemic antifungal therapy for treating Candida auris infections in the central nervous system, particularly following neurotrauma from gunshot wounds. This research highlights potential therapeutic approaches for a challenging fungal infection.
A recent study highlights a case of fatal tension pneumocephalus linked to a central nervous system infection from an extended-spectrum β-lactamase-producing Klebsiella pneumoniae. The research emphasizes the role of hypervirulence-associated genes in this severe infection.