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Type II mixed cryoglobulinemia, a relatively rare clinico-serological subtype of mixed cryoglobulinemia (MC), is an immune complex disorder characterized by purpura, weakness and arthralgia and defined immunochemically by cryoglobulins composed of polyclonal IgGs (autoantigens) and monoclonal IgM (autoantibody).
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for type II mixed cryoglobulinemia.
13 publications have been identified in PubMed for type II mixed cryoglobulinemia. Research spans Case Report / Case Series (62%), Review / Meta-Analysis (15%), and Epidemiology / Natural History (15%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 8 | 62% |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 4:30 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Research summaries
2 |
15% |
Disease patterns and progression | 2 | 15% |
Laboratory research | 1 | 8% |
Mao C (2026). [PMID: 42100418](https://pubmed.ncbi.nlm.nih.gov/42100418/). *Front Oncol*. [Case Report / Case Series]
Crispo F (2026). [PMID: 42239897](https://pubmed.ncbi.nlm.nih.gov/42239897/). *Front Oncol*. [Case Report / Case Series]
Zignego AL (2026). [PMID: 41298332](https://pubmed.ncbi.nlm.nih.gov/41298332/). *Journal of internal medicine*. [Review / Meta-Analysis]
Bouziani E (2025). [PMID: 41316694](https://pubmed.ncbi.nlm.nih.gov/41316694/). *The American journal of case reports*. [Case Report / Case Series]
Mansour B (2025). [PMID: 41164916](https://pubmed.ncbi.nlm.nih.gov/41164916/). *Nephrologie & therapeutique*. [Case Report / Case Series]
Elthes BZ (2025). [PMID: 40210820](https://pubmed.ncbi.nlm.nih.gov/40210820/). *Digestive diseases and sciences*. [Case Report / Case Series]
Thivacaren S (2025). [PMID: 41245923](https://pubmed.ncbi.nlm.nih.gov/41245923/). *Cureus*. [Case Report / Case Series]
Li W (2025). [PMID: 40248336](https://pubmed.ncbi.nlm.nih.gov/40248336/). *Brain & spine*. [Review / Meta-Analysis]
Li W (2025). [PMID: 40831734](https://pubmed.ncbi.nlm.nih.gov/40831734/). *Brain & spine*. [Basic Science / Preclinical]
Xu M (2024). [PMID: 38765016](https://pubmed.ncbi.nlm.nih.gov/38765016/). *Frontiers in immunology*. [Case Report / Case Series]
AI-curated news mentioning type II mixed cryoglobulinemia
Updated Mar 7, 2026
A recent study published in PubMed highlights sustained remission in patients with cryoglobulinemia type II following B-cell-directed therapy. This research may inform future treatment strategies for this rare disease.