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undifferentiated connective tissue syndrome (UCTD) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

undifferentiated connective tissue syndrome

MONDO:0019527

Also known as:UCTD

Find Clinical TrialsTrials

Overview

An autoimmune disorder which does not meet classification criteria used to establish the presence of other well-defined connective tissue diseases.

Clinical Trials4 registered · 3 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include common findings: Anti-dsDNA antibody positivity, Anti-ribosome Po antibody positivity, and Anti-Ro52/TRIM21 antibody positivity.

Organ System	Phenotype Count	Example Features
Lab test results	3	Anti-dsDNA antibody positivity, Anti-ribosome Po antibody positivity, Anti-Ro52/TRIM21 antibody positivity

Explore clinical features

Diagnosis

Biomarker and diagnostic research for undifferentiated connective tissue syndrome has been reported in the published literature.

Prognosis

Phenotype severity distribution: 3 common features.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

4 clinical trials registered, 3 recruiting. Interventions under study include other interventions. Pipeline includes 2 NA. Research is primarily sponsored by academic and government institutions.

76 publications have been identified in PubMed for undifferentiated connective tissue syndrome. Research spans Case Report / Case Series (36%), Epidemiology / Natural History (28%), and Diagnostic / Biomarker (16%).

Research Type	Count	% of Total
Patient case studies	27

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 9:47 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:90002

GARD

Genetic and Rare Diseases Info Center

GARD:19097

Questions for Your Care Team

→Are any of the 4 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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undifferentiated connective tissue syndrome

Overview

Clinical Presentation

Explore clinical features

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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