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undifferentiated high grade pleomorphic sarcoma of bone - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

undifferentiated high grade pleomorphic sarcoma of bone

MONDO:0002618

Also known as:malignant bone fibrous histiocytomamalignant fibrous histiocytoma of bonemalignant fibrous histiocytoma of the bone

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Overview

A rare, high-grade pleomorphic malignant neoplasm arising from the bone. It usually presents with pain which may or may not be associated with swelling in the affected area. It is characterized by the presence of spindle-shaped cells, polygonal or epithelioid cells, multinucleated giant cells, and inflammatory cells. The neoplastic cells exhibit nuclear pleomorphism and high mitotic activity. It metastasizes frequently, most often in the lungs.

Clinical Trials3 registered

ResearchLimited published research (5 articles)

Diagnosis

Biomarker and diagnostic research for undifferentiated high grade pleomorphic sarcoma of bone has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

3 clinical trials registered. Interventions under study include drug therapy, procedural interventions, biologic therapy, and other interventions. Pipeline includes 2 PHASE2, 1 PHASE1. Research is primarily sponsored by academic and government institutions.

6 publications have been identified in PubMed for undifferentiated high grade pleomorphic sarcoma of bone. Research spans Case Report / Case Series (60%), Diagnostic / Biomarker (20%), and Epidemiology / Natural History (20%).

Recent Publications

Ünlü Z (2026). [PMID: 41066667](https://pubmed.ncbi.nlm.nih.gov/41066667/). *Vasc Endovascular Surg*. [Case Report / Case Series]
Riva F (2025). [PMID: 40746603](https://pubmed.ncbi.nlm.nih.gov/40746603/). *Front Oncol*. [Case Report / Case Series]
Öztürk R (2024). [PMID: 39239431](https://pubmed.ncbi.nlm.nih.gov/39239431/). *Indian J Surg Oncol*. [Case Report / Case Series]
Ogura K (2024). [PMID: 38858229](https://pubmed.ncbi.nlm.nih.gov/38858229/). *Int J Clin Oncol*. [Epidemiology / Natural History]

Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 4:33 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

Questions for Your Care Team

→Are any of the 3 active clinical trials a good fit for my situation?
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undifferentiated high grade pleomorphic sarcoma of bone

Overview

Diagnosis

Research Landscape

Recent Publications

Medical References

Related Diseases

Questions for Your Care Team

Questions for Your Care Team