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A retinoblastoma that only involves a single eye.
6 clinical trials registered, 4 recruiting. Interventions under study include other interventions, procedural interventions, drug therapy, and gene therapy. Pipeline includes 2 PHASE2. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06725173](https://clinicaltrials.gov/study/NCT06725173) | Detailed Phenotypic and Genotype Study to Correlate RB1 Mutations Relating to Primary Ocular Tumors and Secondary Extra-ocular Metastasis. |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 11:57 AM UTC
— |
University of Washington |
RECRUITING |
[NCT05504291](https://clinicaltrials.gov/study/NCT05504291) | A Study to Give Treatment Inside the Eye to Treat Retinoblastoma | PHASE2 | Children's Oncology Group | RECRUITING |
[NCT04959097](https://clinicaltrials.gov/study/NCT04959097) | Retinoblastoma Patient Clinical Database and Tissue Repository | — | Children's Hospital Los Angeles | RECRUITING |
[NCT03662776](https://clinicaltrials.gov/study/NCT03662776) | Effect of Treatment Modality on Psychosocial Functioning of Survivors of Unilateral Retinoblastoma | — | Memorial Sloan Kettering Cancer Center | ENROLLING_BY_INVITATION |
[NCT03932786](https://clinicaltrials.gov/study/NCT03932786) | Studying Health Outcomes After Treatment in Patients With Retinoblastoma | — | Vanderbilt-Ingram Cancer Center | RECRUITING |
33 publications have been identified in PubMed for unilateral retinoblastoma. Research spans Basic Science / Preclinical (36%), Epidemiology / Natural History (24%), and Case Report / Case Series (18%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 12 | 36% |
Disease patterns and progression | 8 | 24% |
Patient case studies | 6 | 18% |
Clinical study results | 6 | 18% |
New treatment approaches | 1 | 3% |
Papaioannou K (2026). [PMID: 41924959](https://pubmed.ncbi.nlm.nih.gov/41924959/). *Pediatr Blood Cancer*. [Basic Science / Preclinical]
Rodriguez A (2026). [PMID: 41765171](https://pubmed.ncbi.nlm.nih.gov/41765171/). *Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus*. [Case Report / Case Series]
Rolfe O (2026). [PMID: 41263229](https://pubmed.ncbi.nlm.nih.gov/41263229/). *Clinical & experimental ophthalmology*. [Epidemiology / Natural History]
Dai E (2026). [PMID: 41817519](https://pubmed.ncbi.nlm.nih.gov/41817519/). *JAMA ophthalmology*. [Case Report / Case Series]
Berry JL (2026). [PMID: 41808342](https://pubmed.ncbi.nlm.nih.gov/41808342/). *Clinical & experimental ophthalmology*. [Basic Science / Preclinical]
Ducatelli ME (2026). [PMID: 41643084](https://pubmed.ncbi.nlm.nih.gov/41643084/). *Medicina*. [Basic Science / Preclinical]
Jordan DR (2025). [PMID: 40036817](https://pubmed.ncbi.nlm.nih.gov/40036817/). *Ophthalmic Plast Reconstr Surg*. [Epidemiology / Natural History]
Shahin MN (2025). [PMID: 39582102](https://pubmed.ncbi.nlm.nih.gov/39582102/). *Pediatric blood & cancer*. [Epidemiology / Natural History]
Abdallah HA (2025). [PMID: 40678034](https://pubmed.ncbi.nlm.nih.gov/40678034/). *Ocular oncology and pathology*. [Gene Therapy / Novel Therapeutics]
Toki H (2025). [PMID: 40569505](https://pubmed.ncbi.nlm.nih.gov/40569505/). *Bulletin of mathematical biology*. [Basic Science / Preclinical]