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ventricular tachycardia, familial - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

ventricular tachycardia, familial

MONDO:0008648

Also known as:hereditary ventricular tachycardiaventricular tachycardia, idiopathicfamilial ventricular tachycardia

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Overview

An instance of ventricular tachycardia that is caused by an inherited modification of the individual's genome.

GeneticsMultifactorial, Autosomal dominant · GNAI2 (chr 3)

Clinical Trials1 registered · 1 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Paroxysmal ventricular tachycardia. 4 total HPO annotations.

Organ System	Phenotype Count	Example Features
Heart and blood vessels	4	Paroxysmal ventricular tachycardia, Complete right bundle branch block, Heart muscle disease (cardiomyopathy)

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Genetic Landscape

Assembled from HGNC gene records, ClinGen gene-disease validity evidence, and ClinVar pathogenic variant data. Validity classifications reflect the strength of published evidence linking each gene to this disease.

GNAI2 encodes G protein subunit alpha i2 (355 aa). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. Highest expression in Whole Blood (342.7 TPM) and Lung (222.1 TPM).

Ventricular tachycardia, familial is associated with mutations in the GNAI2 gene on chromosome 3.

GNAI2 is classified as a druggable target with score 2.6.

Diagnosis

Genetic testing for GNAI2 is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for ventricular tachycardia, familial has been reported in the published literature.

Prognosis

Phenotype severity distribution: 1 always present feature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

1 clinical trial registered, 1 recruiting. Interventions under study include medical devices. Pipeline includes 1 NA. Research is primarily industry-sponsored.

32 publications have been identified in PubMed for ventricular tachycardia, familial. Research spans Case Report / Case Series (38%), Epidemiology / Natural History (19%), and Basic Science / Preclinical (16%).

Research Type	Count	% of Total
Patient case studies	12	38%

Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 12:51 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:192605

GARD

Genetic and Rare Diseases Info Center

GARD:2263

Questions for Your Care Team

→Are any of the 1 active clinical trial a good fit for my situation?
→Should I pursue genetic testing for GNAI2, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

ventricular tachycardia, familial

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

GARD

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Post-TAVR Bundle Branch Reentrant Ventricular Tachycardia Managed Without ICD: A Rare Turn of Rhythm.

Exercise-Induced Ventricular Tachycardia Unmasking High-Risk Anomalous Right Coronary Artery in an Adult.

Bidirectional ventricular tachycardia following ricin intoxication: a case report.

ventricular tachycardia, familial

Overview

Clinical Presentation

Explore clinical features

Genetic Landscape

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications

Latest News & Developments

Post-TAVR Bundle Branch Reentrant Ventricular Tachycardia Managed Without ICD: A Rare Turn of Rhythm.

Exercise-Induced Ventricular Tachycardia Unmasking High-Risk Anomalous Right Coronary Artery in an Adult.

Bidirectional ventricular tachycardia following ricin intoxication: a case report.