Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy
Well-differentiated fetal adenocarcinoma (WDFA) of the lung is a rare, primary, low-grade, bronchopulmonary neoplasm characterized by a well-circumscribed, usually large, pulmonary mass that is histologically composed of glycogen-rich neoplastic glands and tubules that resemble fetal lungs at 10 to 16 weeks of gestation and benign adjacent stroma. It typically presents with chest pain, cough, dyspnea, hemoptysis and/or generalized, non-specific symptoms, such as night sweats, lethargy, poor appetite and weight loss.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for well-differentiated fetal adenocarcinoma of the lung.
18 publications have been identified in PubMed for well-differentiated fetal adenocarcinoma of the lung. Research spans Case Report / Case Series (67%), Basic Science / Preclinical (17%), and Other (6%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 12 | 67% |
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 5:41 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Laboratory research
3 |
17% |
Other research | 1 | 6% |
Research summaries | 1 | 6% |
Disease patterns and progression | 1 | 6% |
Mlika M (2026). [PMID: 30480950](https://pubmed.ncbi.nlm.nih.gov/30480950/). *Unknown Journal*. [Other]
Nabe Y (2026). [PMID: 41717591](https://pubmed.ncbi.nlm.nih.gov/41717591/). *Cureus*. [Case Report / Case Series]
Lebedev T (2025). [PMID: 40072065](https://pubmed.ncbi.nlm.nih.gov/40072065/). *Cells*. [Review / Meta-Analysis]
Xu Y (2025). [PMID: 41367635](https://pubmed.ncbi.nlm.nih.gov/41367635/). *Int Med Case Rep J*. [Case Report / Case Series]
Satomi H (2025). [PMID: 41216231](https://pubmed.ncbi.nlm.nih.gov/41216231/). *Cytojournal*. [Case Report / Case Series]
Ahmed A (2025). [PMID: 41198948](https://pubmed.ncbi.nlm.nih.gov/41198948/). *BJC Rep*. [Case Report / Case Series]
Liu H (2025). [PMID: 41049226](https://pubmed.ncbi.nlm.nih.gov/41049226/). *Clin Case Rep*. [Case Report / Case Series]
Evani J (2025). [PMID: 41658026](https://pubmed.ncbi.nlm.nih.gov/41658026/). *J Community Hosp Intern Med Perspect*. [Case Report / Case Series]
Lobo J (2025). [PMID: 40484319](https://pubmed.ncbi.nlm.nih.gov/40484319/). *Mod Pathol*. [Basic Science / Preclinical]
Xu L (2025). [PMID: 39668497](https://pubmed.ncbi.nlm.nih.gov/39668497/). *Clin Nucl Med*. [Case Report / Case Series]
AI-curated news mentioning well-differentiated fetal adenocarcinoma of the lung
Updated Jul 28, 2026
A recent literature review highlights a rare case of early-stage high-grade fetal lung adenocarcinoma associated with a KRAS mutation. This discovery adds to the understanding of the genetic factors involved in this uncommon cancer type.