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A cause of male infertility characterized by X-linked inheritance in which only Sertoli cells (cells that nurture the immature sperm) line the seminiferous tubules (tubes inside the testicles where sperm develop) and there are not any sperm cells present in the seminiferous tubules.
Features include: Gynecomastia, Sertoli cell-only phenotype, and Obesity.
Biomarker and diagnostic research for X-linked spermatogenic failure 1 has been reported in the published literature.
No clinical trials have been registered for X-linked spermatogenic failure 1.
42 publications have been identified in PubMed for X-linked spermatogenic failure 1. Research spans Basic Science / Preclinical (29%), Diagnostic / Biomarker (24%), and Review / Meta-Analysis (17%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 12 | 29% |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 1:01 PM UTC
Online Mendelian Inheritance in Man
Genetic and Rare Diseases Info Center
Common questions about X-linked spermatogenic failure 1
Testing and diagnosis research
10 |
24% |
Research summaries | 7 | 17% |
Patient case studies | 7 | 17% |
Disease patterns and progression | 5 | 12% |
Clinical study results | 1 | 2% |
Valdes-Socin H (2026). [PMID: 41485595](https://pubmed.ncbi.nlm.nih.gov/41485595/). *Ann Endocrinol (Paris)*. [Review / Meta-Analysis]
Leslie SW (2026). [PMID: 30484998](https://pubmed.ncbi.nlm.nih.gov/30484998/). *Unknown Journal*. [Review / Meta-Analysis]
Babakhanzadeh E (2026). [PMID: 42200093](https://pubmed.ncbi.nlm.nih.gov/42200093/). *Int J Reprod Biomed*. [Diagnostic / Biomarker]
Shi H (2026). [PMID: 41297666](https://pubmed.ncbi.nlm.nih.gov/41297666/). *Life Sci*. [Diagnostic / Biomarker]
Jiang X (2026). [PMID: 41616688](https://pubmed.ncbi.nlm.nih.gov/41616688/). *Ecotoxicol Environ Saf*. [Basic Science / Preclinical]
Leps AS (2026). [PMID: 41884496](https://pubmed.ncbi.nlm.nih.gov/41884496/). *JFMS Open Rep*. [Case Report / Case Series]
Tamp E (2026). [PMID: 41951363](https://pubmed.ncbi.nlm.nih.gov/41951363/). *J Clin Pathol*. [Epidemiology / Natural History]
Raffo M (2026). [PMID: 40721164](https://pubmed.ncbi.nlm.nih.gov/40721164/). *Fertil Steril*. [Epidemiology / Natural History]
Hu JY (2025). [PMID: 39363830](https://pubmed.ncbi.nlm.nih.gov/39363830/). *Asian J Androl*. [Diagnostic / Biomarker]
Marić T (2025). [PMID: 39777458](https://pubmed.ncbi.nlm.nih.gov/39777458/). *Hum Mol Genet*. [Basic Science / Preclinical]