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yellow fever (YF) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

yellow fever

MONDO:0020502

Also known as:YFYellow JackYellow fever Virus infection

Find Clinical TrialsTrials

Overview

Yellow fever (YF), caused by YF virus, is a zoonotic disease characterized by fever and constitutional symptoms, with the potential to progress to severe and fatal viral hemorrhagic fever with shock and multi-organ system failure.

Clinical Trials14 registered · 5 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Fever, Nausea, Increased circulating IgM level, and Viremia and others; and common findings: Reduced kidney function (renal insufficiency), Bradycardia, Abnormal bleeding tendency (abnormal bleeding), and Acute kidney injury and others. 47 total HPO annotations.

Organ System	Phenotype Count	Example Features
Digestive system	7	Nausea, Vomiting, Abdominal pain

Diagnosis

Biomarker and diagnostic research for yellow fever has been reported in the published literature.

Prognosis

Phenotype severity distribution: 5 very common features, 18 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

14 clinical trials registered, 5 recruiting. Interventions under study include biologic therapy, other interventions, and procedural interventions. Pipeline includes 2 PHASE4, 2 PHASE3, 2 PHASE2. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT06694766](https://clinicaltrials.gov/study/NCT06694766)

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 6:42 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:99829

GARD

Genetic and Rare Diseases Info Center

GARD:7914

Questions for Your Care Team

→Are any of the 14 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Research summaries	54	30%
Disease patterns and progression	50	27%
Laboratory research	33	18%
Clinical study results	14	8%
Other research	11	6%
Testing and diagnosis research	9	5%
New treatment approaches	9	5%
Patient case studies	2	1%

Kisho

yellow fever

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Yellow fever virus outbreak caused declines in survival and modified dispersal of wild golden lion tamarins.

Telebriefing Transcript: CDC Update on Outbreak of Yellow Fever in Brazil, Vaccination Recommendations - Transcript

CDC Warns Of Deadly Outbreak of Yellow Fever in Brazil - Media Statement

CDC Update on Outbreak of Yellow Fever in Brazil, Vaccination Recommendations - Media Advisory

yellow fever

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Yellow fever virus outbreak caused declines in survival and modified dispersal of wild golden lion tamarins.

Telebriefing Transcript: CDC Update on Outbreak of Yellow Fever in Brazil, Vaccination Recommendations - Transcript

CDC Warns Of Deadly Outbreak of Yellow Fever in Brazil - Media Statement

CDC Update on Outbreak of Yellow Fever in Brazil, Vaccination Recommendations - Media Advisory