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dengue disease (DF) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

dengue disease

MONDO:0005502

Also known as:DFDengueDengue fever

Find Clinical TrialsTrials

Overview

Dengue fever (DF), caused by dengue virus, is an arboviral disease characterized by an initial non-specific febrile illness that can sometimes progress to more severe forms manifesting capillary leakage and hemorrhage (dengue hemorrhagic fever, or DHF) and shock (dengue shock syndrome, or DSS).

TreatmentsNo approved treatments · 4 in pipeline

Clinical Trials2 registered · 2 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Fever and Headache; and common findings: Skin rash, Pruritus, Abdominal pain, and Arthralgia. 22 total HPO annotations.

Organ System	Phenotype Count	Example Features
Digestive system	6	Ascites, Diarrhea, Nausea and vomiting

Diagnosis

Biomarker and diagnostic research for dengue disease has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

No approved treatments are currently available for dengue disease. An additional 4 compounds hold orphan drug designation.

Orphan Drug Designations

While no drugs are FDA-approved specifically for dengue disease, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.

The following drugs have received orphan drug designation from the FDA for dengue disease. Orphan designation reflects regulatory interest and does not indicate approval for treatment.

Brand Name	Generic Name	Sponsor

Prognosis

Phenotype severity distribution: 2 very common features, 4 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

2 clinical trials registered, 2 recruiting. Interventions under study include other interventions. Research is primarily sponsored by academic and government institutions.

331 publications have been identified in PubMed for dengue disease. Research spans Review / Meta-Analysis (31%), Epidemiology / Natural History (27%), and Basic Science / Preclinical (18%).

Research Type	Count	% of Total
Research summaries	97	31%

Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 3:30 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:99828

GARD

Genetic and Rare Diseases Info Center

GARD:6254

Questions for Your Care Team

→Are any of the 2 active clinical trials a good fit for my situation?
→With 4 compounds in the orphan drug pipeline, which are furthest along in development and which clinical trials should I be aware of?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Latest News & Developments

5 recent

View all

AI-curated news mentioning dengue disease

Updated Aug 21, 2026

PubMed Rare Disease•

Science & Discovery

•29 days ago(Aug 21)

Guillain-Barré syndrome following dengue infection in a child in Lebanon: a case report and review of the literature.

A case report highlights Guillain-Barré syndrome developing in a child post-dengue infection in Lebanon, contributing to the understanding of this rare disease's association with viral infections. The review of literature provides insights into similar cases, enhancing awareness among healthcare professionals.

PubMed Rare Disease•

Science & Discovery

•about 2 months ago(Jul 27)

Rapid initiation of standard-volume plasma exchange for acute liver failure from dengue infection.

A new study highlights the rapid initiation of standard-volume plasma exchange as a potential treatment for acute liver failure caused by dengue infection. This research could pave the way for improved management strategies in affected patients.

CDC Newsroom•

Policy & Access

•7 months ago(Feb 25)

Dengue for Health Care Providers

The CDC has released vital guidelines for healthcare providers on the diagnosis, treatment, and prevention of dengue. These guidelines aim to enhance the management of dengue cases and improve patient outcomes.

CDC Newsroom•

Science & Discovery

•7 months ago(Feb 24)

Clinical Features of Dengue

A recent study outlines the clinical features of dengue, which progresses through three phases: febrile, critical, and recovery. Severe cases necessitate hospitalization, highlighting the need for effective management strategies.

PubMed Rare Disease•

Science & Discovery

•7 months ago(Feb 9)

Assessing dengue outbreak risks to blood donation safety, beyond significant outbreak areas in Australia.

A recent study evaluates the risks of dengue outbreaks on blood donation safety in Australia, extending beyond known outbreak areas. This research highlights the need for enhanced monitoring and safety protocols in blood donation practices.

View all news for dengue disease

Kisho

dengue disease

Overview

Clinical Presentation

Diagnosis

Treatment

Orphan Drug Designations

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Clinical Trials

Recent Publications

Latest News & Developments

Guillain-Barré syndrome following dengue infection in a child in Lebanon: a case report and review of the literature.

Rapid initiation of standard-volume plasma exchange for acute liver failure from dengue infection.

Dengue for Health Care Providers

Clinical Features of Dengue

Assessing dengue outbreak risks to blood donation safety, beyond significant outbreak areas in Australia.

dengue disease

Overview

Clinical Presentation

Diagnosis

Treatment

Orphan Drug Designations

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Clinical Trials

Recent Publications

Latest News & Developments

Guillain-Barré syndrome following dengue infection in a child in Lebanon: a case report and review of the literature.

Rapid initiation of standard-volume plasma exchange for acute liver failure from dengue infection.

Dengue for Health Care Providers

Clinical Features of Dengue

Assessing dengue outbreak risks to blood donation safety, beyond significant outbreak areas in Australia.