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A viral encephalitis caused by the St. Louis encephalitis virus (encephalitis virus, st. louis), a flavivirus. It is transmitted to humans and other vertebrates primarily by mosquitoes of the genus culex. The primary animal vectors are wild birds and the disorder is endemic to the midwestern and southeastern United States. Infections may be limited to an influenza-like illness or present as an aseptic meningitis or encephalitis. Clinical manifestations of the encephalitic presentation may include seizures, lethargy, myoclonus, focal neurologic signs, coma, and death. (From Adams et al., Principles of Neurology, 6th ed, p750)
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for st. Louis encephalitis.
42 publications have been identified in PubMed for st. Louis encephalitis. Research spans Basic Science / Preclinical (45%), Epidemiology / Natural History (36%), and Case Report / Case Series (10%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 19 | 45% |
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 3:53 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
15 |
36% |
Patient case studies | 4 | 10% |
Research summaries | 2 | 5% |
Other research | 1 | 2% |
New treatment approaches | 1 | 2% |
Soares AP (2026). [PMID: 42146096](https://pubmed.ncbi.nlm.nih.gov/42146096/). *Front Cell Infect Microbiol*. [Basic Science / Preclinical]
Fallon G (2026). [PMID: 42059622](https://pubmed.ncbi.nlm.nih.gov/42059622/). *J Virol*. [Basic Science / Preclinical]
Cervantes Rincón T (2026). [PMID: 41993435](https://pubmed.ncbi.nlm.nih.gov/41993435/). *bioRxiv*. [Basic Science / Preclinical]
Gervais A (2026). [PMID: 41570068](https://pubmed.ncbi.nlm.nih.gov/41570068/). *Proc Natl Acad Sci U S A*. [Case Report / Case Series]
Lewis SN (2026). [PMID: 41825898](https://pubmed.ncbi.nlm.nih.gov/41825898/). *J Am Mosq Control Assoc*. [Epidemiology / Natural History]
Sterling CE (2026). [PMID: 42039581](https://pubmed.ncbi.nlm.nih.gov/42039581/). *bioRxiv*. [Basic Science / Preclinical]
Kneubehl AR (2026). [PMID: 41986946](https://pubmed.ncbi.nlm.nih.gov/41986946/). *Emerg Infect Dis*. [Epidemiology / Natural History]
Mansilla AP (2026). [PMID: 41928396](https://pubmed.ncbi.nlm.nih.gov/41928396/). *Med Vet Entomol*. [Epidemiology / Natural History]
Hayashi DJ (2026). [PMID: 41849539](https://pubmed.ncbi.nlm.nih.gov/41849539/). *Mem Inst Oswaldo Cruz*. [Basic Science / Preclinical]
Frey ZD (2025). [PMID: 41313001](https://pubmed.ncbi.nlm.nih.gov/41313001/). *J Virol*. [Basic Science / Preclinical]