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Zygomycosis - Clinical Profile, Treatments & Trials | Kisho | Kisho

Rare Disease

Zygomycosis

MONDO:0019136

Also known as:MucormycosisZygomycota infectious disease

Find Clinical TrialsTrials

Overview

Any infection due to a fungus of the Zygomycota phylum. The disease typically involves the rhino-facial-cranial area, lungs, gastrointestinal tract, skin, or less commonly other organ systems. The infecting fungi have a predilection for invading vessels of the arterial system, causing embolization and subsequent necrosis of surrounding tissue.

Treatments1 FDA approved

Clinical Trials13 registered · 7 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include common findings: Sinusitis, Fever, Fatigue, and Pain and others; and sometimes findings: Visual loss, Blurred vision, Periorbital fullness, and Diabetes mellitus and others. 76 total HPO annotations.

Organ System	Phenotype Count	Example Features
Digestive system	10	Vomiting, Diarrhea, Nausea

Diagnosis

Biomarker and diagnostic research for Zygomycosis has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

1 FDA-approved treatment is available for Zygomycosis, including ISAVUCONAZONIUM SULFATE (CRESEMBA, approved 2015). An additional 1 compound holds orphan drug designation.

Approved Therapies

Brand Name	Generic Name	Mechanism	Approved	Market Status

Prognosis

Phenotype severity distribution: 6 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

13 clinical trials registered, 7 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and biologic therapy. Pipeline includes 1 PHASE4, 1 PHASE2, 1 PHASE1. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT05406037](https://clinicaltrials.gov/study/NCT05406037)

Data assembled from 6 of 12 sources · Last updated Sep 19, 2026, 1:58 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:73263

GARD

Genetic and Rare Diseases Info Center

GARD:10224

Questions for Your Care Team

→What are the benefits and potential side effects of CRESEMBA for managing Zygomycosis?
→Are any of the 13 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Patient case studies	88	37%
Research summaries	50	21%
Disease patterns and progression	42	17%
Testing and diagnosis research	22	9%
Laboratory research	18	7%
Clinical study results	10	4%
New treatment approaches	7	3%
Other research	4	2%

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Zygomycosis

Overview

Clinical Presentation

Diagnosis

Treatment

Approved Therapies

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Orphan Drug Designations

Clinical Trials

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Zygomycosis

Overview

Clinical Presentation

Diagnosis

Treatment

Approved Therapies

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Orphan Drug Designations

Clinical Trials

Recent Publications