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optimizing oligonucleotide therapeutics a model informed drug development perspective
Original title: “Optimizing Oligonucleotide Therapeutics: A Model-Informed Drug Development Perspective.”
survival and clinical progression in barth syndrome insights from the barth syndrome foundation s database of 502 affected individuals
Original title: “Survival and Clinical Progression in Barth Syndrome: Insights From the Barth Syndrome Foundation's Database of 502 Affected Individuals.”
progenitors from distinct perichondrium layers initiate tumor formation in hereditary multiple osteochondromas as revealed in a mouse model
Original title: “Progenitors from distinct perichondrium layers initiate tumor formation in hereditary multiple osteochondromas as revealed in a mouse model.”
pancreatic acinar cell cystadenoma single center experiences and a systematic review
Original title: “Pancreatic acinar cell cystadenoma: single-center experiences and a systematic review.”
diagnostic and therapeutic challenges in anti nmda receptor encephalitis associated with an ovarian immature teratoma
Original title: “Diagnostic and therapeutic challenges in anti-NMDA receptor encephalitis associated with an ovarian immature teratoma.”
serous cystadenoma of the pancreatic head associated with pancreatic duct atresia and acinar cell loss a case report
Original title: “Serous cystadenoma of the pancreatic head associated with pancreatic duct atresia and acinar cell loss: a case report.”
severe peripheral neuropathy secondary to acute intermittent porphyria caused by a rare hmbs gene mutation a case report
Original title: “Severe peripheral neuropathy secondary to acute intermittent porphyria caused by a rare HMBS gene mutation: a case report.”
lipoid pneumonia mimicking lung cancer a retrospective case series and literature review
Original title: “Lipoid pneumonia mimicking lung cancer: a retrospective case series and literature review.”
optic disc neovascularization in inflammatory eye diseases a review of pathogenesis clinical features and management
Original title: “Optic disc neovascularization in inflammatory eye diseases: A review of pathogenesis, clinical features, and management.”
unusual hypertrophic cardiomyopathy with severe right ventricular outflow tract obstruction and two septal aneurysms a case report
Original title: “Unusual hypertrophic cardiomyopathy with severe right ventricular outflow tract obstruction and two septal aneurysms: a case report.”
anca associated vasculitis with thoracic spinal canal dural involvement and hypertrophic cranial pachymeningitis a case report
Original title: “ANCA-associated vasculitis with thoracic spinal canal dural involvement and hypertrophic cranial pachymeningitis: A case report.”
clinical review of congenital and perinatal infections from womb to follow up
Original title: “A Clinical Review of Congenital and Perinatal Infections: From Womb to Follow-Up.”
wrong level spinal surgery a multicentre analysis of 34 544 consecutive cases
Original title: “Wrong-level spinal surgery : a multicentre analysis of 34,544 consecutive cases.”
tapentadol induced urticarial rash in a patient with acute pancreatitis
Original title: “Tapentadol-induced urticarial rash in a patient with acute pancreatitis.”
high grade b cell lymphoma of the penis in a cat
Original title: “High-grade B-cell lymphoma of the penis in a cat.”
UK spin‑out speeds up development and reduces animal testing
Original title: “Myomaker Bio unveils lab‑grown human muscle platform to transform drug testing”
Adaptive Trial Design AI in Clinical ... Clinical Trials DHT Digital Health Technologies eClinical Tech News Electroconvulsive Therapy EMA Executive Interviews FDA FDA Guidance FDA Regulatory Strategy Immuno-Oncology Ketamine Therapy Magnetic Seizure Therapy Neuromodulation Opinion Patient Stratification Pediatric Oncology Pfizer Precision Oncology Psychedelics Rare Disease RBQM Real-World Evidence RWD RWE Treatment-Resistant ... Adaptive Trial Design AI in Clinical Trials Alzheimer's Disease Article Artificial Intelligence in Clinical Trials Clinical Operations Clinical Research Clinical Trial Design Clinical Trial Diversity Clinical Trial Innovation Clinical Trial Payments Clinical Trial Quality Clinical Trials CNS Trials Conference Coverage Data Analysis Data Integrity Data Management DCT Decentralized Clinical Trials DHT Digital Health Technologies eClinical Tech News Electroconvulsive Therapy EMA Executive Interviews FDA FDA Guidance FDA Regulatory Strategy Immuno-Oncology Ketamine Therapy Magnetic Seizure Therapy Neuromodulation Opinion Patient Stratification Pediatric Oncology Pfizer Precision Oncology Psychedelics Rare Disease RBQM Real-World Evidence RWD RWE Treatment-Resistant Depression For decades, respiratory medicine has measured what patients do during the day—spirometry in clinic, symptom diaries filled out imperfectly, exacerbations counted after the fact. What it has largely failed to measure is what happens to patients while they sleep: the eight hours when, for asthma, COPD, heart failure, and a growing list of chronic diseases, Mikesh Udani: Large pharma are already using it in their clinical trials globally. We started with respiratory and have now entered oncology. Rare diseases, neurology, and cardiovascular are next. So far it’s been used to measure quality of life, recovery, and response to treatment, and as a tool to trigger clinician assessment in case of symptom flare-ups. Mikesh Udani CEO, Albus Health For decades, respiratory medicine has measured what patients do during the day—spirometry in clinic,...
Original title: “The Eight Hours Clinicians Ignored: How Albus Health Is Turning Sleep Into a Clinical Endpoint”
Clinical trial suggests semaglutide may help patients with alcohol use disorder and obesity.
Original title: “Adding weekly GLP-1 to cognitive behavioral therapy further reduces heavy drinking ”