A recent study identifies a distinct mutational signature and clonal evolution in high-grade gliomas associated with constitutional mismatch repair deficiency. This research enhances understanding of the genetic underpinnings of these tumors, potentially guiding future therapeutic strategies.
distinct mutational signature and clonal evolution in constitutional mismatch repair deficiency associated high grade gliomas
Original title: “Distinct mutational signature and clonal evolution in constitutional mismatch repair deficiency-associated high-grade gliomas.”