Acrocardiofacial syndrome (ACFS) is a rare genetic disorder that affects multiple parts of the body. It is characterized by a variety of features including split-hand/split-foot malformation, facial anomalies, and cleft lip or palate. In addition to structural differences in the hands and feet, people with ACFS may also have congenital heart defects, genital anomalies, and intellectual challenges. The wide range of symptoms can make the condition complex, and care typically involves a team of specialists to address the multiple areas affected.

People with acrocardiofacial syndrome might show several symptoms such as split-hand/split-foot malformation, facial anomalies, and cleft lip or palate. They may also experience congenital heart defects, genital anomalies, and intellectual deficits.

Acrocardiofacial syndrome is described as a rare genetic disorder. Although the condition is genetic in nature, specific genes or genetic mutations have not been identified in the provided sources.