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A benign or malignant neuroendocrine neoplasm of the sympathetic nervous system that secretes catecholamines. It arises from the chromaffin cells of the adrenal medulla. Clinical presentation includes headaches, palpitations, chest and abdominal pain, hypertension, fever, and tremor. Microscopically, a characteristic nesting (zellballen) growth pattern is usually seen. Other growth patterns including trabecular pattern may also be present.
Biomarker and diagnostic research for adrenal gland pheochromocytoma has been reported in the published literature.
53 clinical trials registered, 26 recruiting. Interventions under study include drug therapy, other interventions, procedural interventions, and biologic therapy. Pipeline includes 1 PHASE4, 17 PHASE2, 7 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT06523582](https://clinicaltrials.gov/study/NCT06523582) |
Data assembled from 3 of 12 sources · Last updated Nov 4, 2026, 10:15 AM UTC
Common questions about adrenal gland pheochromocytoma
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients |
— |
Universidad Nacional Autonoma de Mexico |
RECRUITING |
[NCT06444607](https://clinicaltrials.gov/study/NCT06444607) | Hereditary Pheochromocytoma Assessment of Tumour Immunologies | — | Radboud University Medical Center | RECRUITING |
[NCT03344016](https://clinicaltrials.gov/study/NCT03344016) | Multicenter Pheochromocytoma and Paraganglioma Evaluation | NA | Felix Beuschlein | RECRUITING |
[NCT07288931](https://clinicaltrials.gov/study/NCT07288931) | Al18F-NOTA-LM3 PET/CT in Patients With Pheochromocytoma and Paraganglioma | NA | Peking Union Medical College Hospital | RECRUITING |
[NCT06683846](https://clinicaltrials.gov/study/NCT06683846) | Ivonescimab in the Treatment of Multiple Advanced Tumors | PHASE2 | Fudan University | RECRUITING |
141 publications have been identified in PubMed for adrenal gland pheochromocytoma. Research spans Review / Meta-Analysis (51%), Diagnostic / Biomarker (11%), and Basic Science / Preclinical (11%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 63 | 51% |
Testing and diagnosis research | 14 | 11% |
Laboratory research | 14 | 11% |
Patient case studies | 12 | 10% |
Disease patterns and progression | 12 | 10% |
Clinical study results | 5 | 4% |
Other research | 2 | 2% |
New treatment approaches | 1 | 1% |
Mahmood E (2026). [PMID: 30969728](https://pubmed.ncbi.nlm.nih.gov/30969728/). *Unknown Journal*. [Case Report / Case Series]
Halperin R (2026). [PMID: 41783997](https://pubmed.ncbi.nlm.nih.gov/41783997/). *Eur J Endocrinol*. [Epidemiology / Natural History]
Decmann A (2026). [PMID: 41532570](https://pubmed.ncbi.nlm.nih.gov/41532570/). *Endocr Relat Cancer*. [Review / Meta-Analysis]
Park MJ (2026). [PMID: 41781348](https://pubmed.ncbi.nlm.nih.gov/41781348/). *J Intern Med*. [Epidemiology / Natural History]
Alkaissi H (2026). [PMID: 42067273](https://pubmed.ncbi.nlm.nih.gov/42067273/). *Endocrinol Metab Clin North Am*. [Review / Meta-Analysis]
Jena S (2026). [PMID: 41736347](https://pubmed.ncbi.nlm.nih.gov/41736347/). *J Pak Med Assoc*. [Review / Meta-Analysis]
Berber E (2026). [PMID: 42104782](https://pubmed.ncbi.nlm.nih.gov/42104782/). *J Laparoendosc Adv Surg Tech A*. [Other]
Bridwell RE (2026). [PMID: 41656028](https://pubmed.ncbi.nlm.nih.gov/41656028/). *Endocrinol Metab Clin North Am*. [Review / Meta-Analysis]
Alkaissi H (2026). [PMID: 41043588](https://pubmed.ncbi.nlm.nih.gov/41043588/). *Endocr Pract*. [Epidemiology / Natural History]
Phadte A (2026). [PMID: 41956124](https://pubmed.ncbi.nlm.nih.gov/41956124/). *Horm Metab Res*. [Review / Meta-Analysis]
AI-curated news mentioning adrenal gland pheochromocytoma
Updated Oct 8, 2026
Recent research using single-cell transcriptomics has uncovered significant transcriptional reprogramming and microenvironmental changes in ectopic ACTH/CRH-secreting pheochromocytomas. These findings could enhance understanding of tumor biology and inform future therapeutic strategies.
A case report highlights pediatric pheochromocytoma characterized by rapid cyclic blood pressure fluctuations. This study contributes to the understanding of this rare tumor's clinical presentation in children.
A recent study highlights the diagnostic challenges of PTHrP-mediated hypercalcemia in metastatic adrenocortical carcinoma, which can mimic pheochromocytoma. This research underscores the need for careful differentiation in clinical settings.