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A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
Biomarker and diagnostic research for AIDS dementia complex has been reported in the published literature.
2 clinical trials registered, 1 recruiting. Interventions under study include drug therapy and other interventions. Pipeline includes 1 PHASE1. Research is primarily sponsored by academic and government institutions.
93 publications have been identified in PubMed for AIDS dementia complex. Research spans Review / Meta-Analysis (38%), Basic Science / Preclinical (22%), and Epidemiology / Natural History (18%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 35 | 38% |
Laboratory research | 20 | 22% |
Disease patterns and progression | 17 | 18% |
Testing and diagnosis research | 11 | 12% |
Clinical study results | 4 | 4% |
New treatment approaches | 4 | 4% |
Patient case studies | 2 | 2% |
Williams ME (2026). [PMID: 42213325](https://pubmed.ncbi.nlm.nih.gov/42213325/). *Adv Exp Med Biol*. [Review / Meta-Analysis]
Scuderi G (2026). [PMID: 41751579](https://pubmed.ncbi.nlm.nih.gov/41751579/). *Genes (Basel)*. [Basic Science / Preclinical]
Corley MJ (2026). [PMID: 42127254](https://pubmed.ncbi.nlm.nih.gov/42127254/). *Top Antivir Med*. [Review / Meta-Analysis]
Trivedi R (2026). [PMID: 42194076](https://pubmed.ncbi.nlm.nih.gov/42194076/). *Biomolecules*. [Review / Meta-Analysis]
Wang G (2026). [PMID: 42095976](https://pubmed.ncbi.nlm.nih.gov/42095976/). *J Neurovirol*. [Clinical Trial Publication]
Kopstein M (2026). [PMID: 29939522](https://pubmed.ncbi.nlm.nih.gov/29939522/). *Unknown Journal*. [Review / Meta-Analysis]
Panholzer J (2026). [PMID: 41772356](https://pubmed.ncbi.nlm.nih.gov/41772356/). *J Neurovirol*. [Epidemiology / Natural History]
Zheng Y (2026). [PMID: 41203503](https://pubmed.ncbi.nlm.nih.gov/41203503/). *Neurotherapeutics*. [Basic Science / Preclinical]
Nakao A (2026). [PMID: 41566335](https://pubmed.ncbi.nlm.nih.gov/41566335/). *AIDS Res Ther*. [Gene Therapy / Novel Therapeutics]
Santerre M (2026). [PMID: 42198698](https://pubmed.ncbi.nlm.nih.gov/42198698/). *Viruses*. [Review / Meta-Analysis]
Data assembled from 3 of 12 sources · Last updated Sep 18, 2026, 6:21 PM UTC
Genetic and Rare Diseases Info Center
Common questions about AIDS dementia complex