Ampulla of Vater Adenocarcinoma — Clinical Trials

MONDO:00026706 active·6 recruitingLast updated: Mar 20, 2026, 3:58 PM

Trial Landscape

Ampulla of Vater Adenocarcinoma has a growing clinical research program, driven by drug treatment and procedure.

Recruiting

Active Trials

By Approach

Drug Treatment3

Procedure3

Biological Therapy2

3 additional trials involve behavioral, dietary, diagnostic, or observational approaches.

By Phase

Phase 1

Phase 2

Phase 3

Phase 4

2 trials are observational or have no phase designation.

Sponsor Types

Academic/Other6

Trial Locations

France2 trials

United States2 trials

Netherlands1 trial

Italy1 trial

Trials often recruit across multiple countries, so totals exceed the trial count.

6 Trials

Phase 3Recruiting

NCT06813976

PRODIGE 98 : Randomized, Multicenter Phase 3 Trial of Adjuvant Chemotherapy With Modified FOLFIRINOX Versus Capecitabine or Gemcitabine in Patients With Resected Ampullary Adenocarcinoma

Sponsor:Centre Hospitalier Universitaire Dijon

FranceStarted: Jul 2025Est. completion: Jul 2033Updated: Jul 2025

Phase 2Recruiting

NCT07282912

Trial Comparing Standard of Care Therapy With and Without Sequential Cytoreductive Intervention for Patients With Metastatic Foregut Adenocarcinoma and Undetectable Circulating Tumor-Deoxyribose Nucleic Acid (ctDNA) Levels

Sponsor:Yale University

United StatesStarted: Mar 2026Est. completion: Jun 2028Updated: Mar 2026

Phase 1Recruiting

NCT05116072

Efficacy and Safety of TPIAT for Resectable Adenocarcinoma of the Pancreas Region at High Risk of Postoperative Fistula

Sponsor:University Hospital, Lille

FranceStarted: Feb 2022Est. completion: Feb 2030Updated: Sep 2025

Phase 4Recruiting

NCT07262957

Preventing Postoperative Complications in Patients Undergoing High-risk Pancreatoduodenectomy With a Bundle Approach Including Hydrocortisone, Octreotide, and the Teres Ligament Patch (PANENCA)

Sponsor:Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

NetherlandsStarted: Sep 2025Est. completion: Dec 2027Updated: Dec 2025

Not ApplicableRecruiting

NCT02757859

High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery

Sponsor:Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

United StatesStarted: Apr 2016Est. completion: Apr 2026Updated: May 2025

Recruiting

NCT06068023

The ADAPTA Study: ADjuvant chemotherAPy After Curative Intent resecTion of Ampullary Cancer.

Sponsor:Fondazione Poliambulanza Istituto Ospedaliero

ItalyStarted: Jul 2023Est. completion: Jul 2029Updated: Oct 2023

Last updated over 18 months ago

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Data sourced from ClinicalTrials.gov via Kisho's automated pipeline. Trials refreshed every 4 hours for monitored diseases.

Last sync: March 20, 2026 at 3:58 PM