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Aortic arch interruption is a rare heart defect characterized by complete lack of anatomical continuity between the transverse aortic arch and the descending thoracic aorta. AAI should be distinguished anatomically from atresia of the aortic arch where continuity between these segments is achieved by an imperforate fibrous strand of various lengths.
Biomarker and diagnostic research for aortic arch interruption has been reported in the published literature.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for aortic arch interruption.
16 publications have been identified in PubMed for aortic arch interruption. Research spans Case Report / Case Series (75%), Diagnostic / Biomarker (6%), and Clinical Trial Publication (6%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 12 | 75% |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 2:51 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
1 |
6% |
Clinical study results | 1 | 6% |
Laboratory research | 1 | 6% |
Disease patterns and progression | 1 | 6% |
Wang L (2026). [PMID: 41335067](https://pubmed.ncbi.nlm.nih.gov/41335067/). *JACC Case Rep*. [Case Report / Case Series]
Zhang X (2026). [PMID: 42254408](https://pubmed.ncbi.nlm.nih.gov/42254408/). *Front Med (Lausanne)*. [Case Report / Case Series]
Razzuk A (2026). [PMID: 42095914](https://pubmed.ncbi.nlm.nih.gov/42095914/). *Pediatr Cardiol*. [Case Report / Case Series]
Yang Y (2026). [PMID: 41996300](https://pubmed.ncbi.nlm.nih.gov/41996300/). *Am J Case Rep*. [Case Report / Case Series]
García Rojas F (2025). [PMID: 40767166](https://pubmed.ncbi.nlm.nih.gov/40767166/). *Cardiol Young*. [Case Report / Case Series]
Roopesh BVS (2025). [PMID: 40969964](https://pubmed.ncbi.nlm.nih.gov/40969964/). *Ann Pediatr Cardiol*. [Case Report / Case Series]
Yi G (2025). [PMID: 41395307](https://pubmed.ncbi.nlm.nih.gov/41395307/). *Front Pediatr*. [Case Report / Case Series]
Provost B (2025). [PMID: 40574475](https://pubmed.ncbi.nlm.nih.gov/40574475/). *Interdiscip Cardiovasc Thorac Surg*. [Case Report / Case Series]
Orioli V (2025). [PMID: 41263973](https://pubmed.ncbi.nlm.nih.gov/41263973/). *Pediatr Cardiol*. [Epidemiology / Natural History]
Suc V (2025). [PMID: 40122796](https://pubmed.ncbi.nlm.nih.gov/40122796/). *BMC Pediatr*. [Case Report / Case Series]
AI-curated news mentioning aortic arch interruption
Updated Jul 17, 2026
A recent study discusses the surgical management of an acquired aortic interruption in an adult, initially suspected due to severe aortic coarctation and significant collateral circulation. This research contributes to the understanding of complex cardiovascular conditions.