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premature closure of the arterial duct - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

premature closure of the arterial duct

MONDO:0019823

Also known as:premature closure of the patent ductus arteriosus

Overview

Premature closure of the arterial duct is a rare arterial duct anomaly, defined as a significant constriction or closure of the fetal arterial duct in the absence of structural heart defects with pathognomonic features of increased right ventricular afterload, tricuspid regurgitation and, consequently, right atrial dilation and right ventricular hypertrophy. The severity of symptoms is related to the degree and rate of ductal constriction and ranges from mild postnatal respiratory distress to development of ventricular failure with fetal hydrops and intrauterine death or severe cardiopulmonary compromise in the postnatal period. It may be associated with a prenatal exposure to cyclooxygenase inhibitors or corticosteroids.

Diagnosis

Biomarker and diagnostic research for premature closure of the arterial duct has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for premature closure of the arterial duct.

135 publications have been identified in PubMed for premature closure of the arterial duct. Research spans Clinical Trial Publication (33%), Epidemiology / Natural History (25%), and Review / Meta-Analysis (20%).

Research Type	Count	% of Total
Clinical study results	41	33%

Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 9:33 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:95486

GARD

Genetic and Rare Diseases Info Center

GARD:19271

Questions for Your Care Team

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premature closure of the arterial duct

Overview

Diagnosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

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