Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

autosomal dominant Parkinson disease 4 - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

autosomal dominant Parkinson disease 4

MONDO:0011562

Also known as:autosomal dominant Lewy body Parkinson disease 4autosomal dominant Parkinson disease type 4PARK4

Find Clinical TrialsTrials

Overview

A late onset Parkinson disease that has material basis in heterozygous triplication of the alpha-synuclein gene (SNCA) on chromosome 4q22.

GeneticsAutosomal dominant · SNCA (chr 4)

Clinical Trials6 registered · 4 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include: Lewy bodies, Parkinsonism, Orthostatic hypotension, and Problems with involuntary body functions (abnormal autonomic nervous system physiology) and 4 more.

Organ System	Phenotype Count	Example Features
Brain and nerves	5	Parkinsonism, Problems with involuntary body functions (abnormal autonomic nervous system physiology), Hallucinations

Genetic Landscape

SNCA function has not been fully characterized.

Autosomal dominant Parkinson disease 4 is associated with mutations in the SNCA gene on chromosome 4.

Diagnosis

Genetic testing for SNCA is available. Testing is considered confirmatory for diagnosis.

Biomarker and diagnostic research for autosomal dominant Parkinson disease 4 has been reported in the published literature.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

6 clinical trials registered, 4 recruiting. Interventions under study include other interventions and procedural interventions. Pipeline includes 1 EARLY_PHASE1. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT04724941](https://clinicaltrials.gov/study/NCT04724941)

Data assembled from 6 of 12 sources · Last updated Sep 18, 2026, 7:17 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:605543

GARD

Genetic and Rare Diseases Info Center

GARD:18475

Questions for Your Care Team

→Are any of the 6 active clinical trials a good fit for my situation?
→Should I pursue genetic testing for SNCA, and what would the results mean for my family?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Laboratory research	7	37%
Patient case studies	4	21%
Disease patterns and progression	4	21%
Research summaries	2	11%
Testing and diagnosis research	1	5%
Clinical study results	1	5%

Kisho

autosomal dominant Parkinson disease 4

Overview

Clinical Presentation

Genetic Landscape

Diagnosis

Research Landscape

Medical References

External Resources

OMIM

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

autosomal dominant Parkinson disease 4

Overview

Clinical Presentation

Genetic Landscape

Diagnosis

Research Landscape

Medical References

External Resources

OMIM

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications