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benign paroxysmal positional vertigo (BPPV) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

benign paroxysmal positional vertigo

MONDO:8000018

Also known as:BPPVBRVbenign paroxysmal positional nystagmus

Find Clinical TrialsTrials

Overview

Idiopathic recurrent vertigo associated with positional nystagmus. It is associated with a vestibular loss without other neurological or auditory signs. Unlike in labyrinthitis and vestibular neuronitis inflammation in the ear is not observed.

GeneticsAutosomal dominant

Clinical Trials15 registered · 8 recruiting

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include always present findings: Vertigo, Oscillopsia, and Gait imbalance. 4 total HPO annotations.

Organ System	Phenotype Count	Example Features
Ears	2	Hearing loss (hearing impairment), Vertigo
Brain and nerves

Diagnosis

Biomarker and diagnostic research for benign paroxysmal positional vertigo has been reported in the published literature.

Prognosis

Phenotype severity distribution: 3 always present features.

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

15 clinical trials registered, 8 recruiting. Interventions under study include procedural interventions, other interventions, medical devices, and drug therapy. Pipeline includes 11 NA. Research is primarily sponsored by academic and government institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT06738823](https://clinicaltrials.gov/study/NCT06738823)

Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 5:30 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

OMIM

Online Mendelian Inheritance in Man

OMIM:193007

Questions for Your Care Team

→Are any of the 15 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Disease patterns and progression	76	29%
Research summaries	68	26%
Clinical study results	59	22%
Testing and diagnosis research	24	9%
Laboratory research	19	7%
Patient case studies	15	6%
Other research	5	2%

Kisho

benign paroxysmal positional vertigo

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Vestibular deficit and recovery in rare forms of benign paroxysmal positional vertigo with downbeat nystagmus.

benign paroxysmal positional vertigo

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

OMIM

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Vestibular deficit and recovery in rare forms of benign paroxysmal positional vertigo with downbeat nystagmus.