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NIH Grants & Funding for Chagas Disease | Kisho | Kisho

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Chagas Disease — NIH Grants & Funding

Active and recent NIH-funded research on Chagas Disease. Data from NIH RePORTER, last 36 months.

MONDO:0001444

NIH-funded research on Chagas Disease

active grants

institutions

researchers

new in last 12 mo.

$56.5M in NIH funding over the last 36 months. Data from NIH RePORTER.

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Basic Science(23)

Basic ScienceR01Active

Mechanisms of myocarditis and progressive cardiac fibrosis in chronic Trypanosoma cruzi infection.

Jones, Kathryn·BAYLOR COLLEGE OF MEDICINE·HOUSTON, TX

$704,944 (FY2026)

Chagas Disease — NIH Grants & Funding

Basic Science(23)

Mechanisms of myocarditis and progressive cardiac fibrosis in chronic Trypanosoma cruzi infection.

Oxidative Response Networks in Chagasic Cardiomyopathy

Elucidating the Role of Endocytosis Via the Cytostome in the Life Cycle of Trypanosoma cruzi

Regulation of RNA editing in two life cycle stages of Trypanosoma brucei

Characterization of cAMP signaling microdomains in the human pathogen Trypanosoma cruzi

Identification and function of mechanosensitive channels in Trypanosoma cruzi

Barcode screening of essential protein kinases in the life cycle progression of Trypanosoma cruzi

Targeting HNF4-induced thrombo-inflammation in Chagas disease

Immunoregulation of cellular immunity and tissue homeostasis during Chagas' disease

Unravelling of protein trafficking in Trypanosoma cruzi, the agent of Chagas disease.

Translational(11)

Trypanocidal Agents that Kill Multiple Stages of the Trypanosoma cruzi Life Cycle

Integrin activator-adjuvanted DNA vaccine against Trypanosoma cruzi infection

Drug Discovery for Chagas Disease

New chemotherapy regimens and biomarkers for Chagas disease

Nanotherapeutic strategies for the treatment of chronic Chagas Disease

Deciphering the mechanism of action of carnitine, a novel treatment for chronic Chagas disease

Validation of Trypanosoma cruzi dihydroorotate dehydrogenase as a drug target for Chagas´disease.

Developing methionyl tRNA synthetase inhibitors as therapeutics for Chagas disease

New Treatments for Chronic Chagas Disease

SELF-MASKED ALDEHYDES AS INHIBITORS OF THE CYSTEINE PROTEASES 3CL PROTEASE, CATHEPSIN L, AND CRUZAIN

Clinical(4)

Non-inferiority trial of a therapeutic vaccine against Chagas disease in naturally-infected rhesus macaques

Treatment outcome requirements for disease prevention in Chagas disease

"Sao Paulo-Minas Gerais Center for Chagas Disease Treatment (SaMiTrop)"

Short-course Benznidazole Treatment to Reduce Trypanosoma cruzi Parasitic Load in Women of Reproductive Age: A Non-inferiorityRandomized Controlled Trial

Epi / Nat. History(5)

Determining function and mechanism of lncRNA Chast in Trypanosoma cruzi infection and dissemination

Polyphosphate and cardiac fibrosis by Trypanosoma cruzi

An integrated approach to understand and diagnose congenital Chagas disease

Deciphering the immunologic landscape of Chagas cardiomyopathy pathogenesis

Predictors of cardiomyopathy progression in a Chagas disease cohort in Bolivia

Biomarker / Dx(7)

Biomarker-Based Test of Cure for Chagas Disease

Optimization of UltraPCR for detection of and assessment of treatment outcomes in Trypanosoma cruzi infection

Development of Diagnostic Antibodies for Acute and Chronic Chagas Disease

Evaluation of a novel Tc-24 ELISA test in post-treatment efficacy for Chagas disease.

High-throughput analysis of dynamics of antibody responses against defined epitopes: prioritization of diagnostic and prognostic markers for Chagas disease

Small molecule biomarkers of cardiac Chagas disease progression

Optimizing blood PCR as test of cure in Chagas disease

Medical Device(4)

Point-of-care diagnostic test for T. cruzi (Chagas) infection

Development of Next-gen Chagas DetectTM Plus Rapid test for sensitive and specific diagnosis of Chagas disease

Diagnostic assay for congenital Chagas disease

Kissing bug kill trap for control of Trypanosoma cruzi infection