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A rare form of mast cell leukemia characterized by the presence of at least 20% mast cells in bone marrow aspirate smears but often mature mast cell morphology, low proliferation rate, and absence of organ damage and C findings (cytopenias, hepatomegaly, ascites, portal hypertension, splenomegaly, skeletal lesions, malabsorption). The disease course is less aggressive than in the acute form, although patients may later progress.
Biomarker and diagnostic research for chronic mast cell leukemia has been reported in the published literature.
No clinical trials have been registered for chronic mast cell leukemia.
7 publications have been identified in PubMed for chronic mast cell leukemia. Research spans Review / Meta-Analysis (29%), Case Report / Case Series (29%), and Clinical Trial Publication (29%).
Lin CY (2026). [PMID: 41451440](https://pubmed.ncbi.nlm.nih.gov/41451440/). *Orthopaedic surgery*. [Diagnostic / Biomarker]
Gupta A (2025). [PMID: 40105009](https://pubmed.ncbi.nlm.nih.gov/40105009/). *International journal of laboratory hematology*. [Case Report / Case Series]
Leguit RJ (2025). [PMID: 40795827](https://pubmed.ncbi.nlm.nih.gov/40795827/). *American journal of clinical pathology*. [Review / Meta-Analysis]
Ramakanth R (2025). [PMID: 39343075](https://pubmed.ncbi.nlm.nih.gov/39343075/). *Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association*. [Clinical Trial Publication]
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 11:12 AM UTC
European rare disease database
Genetic and Rare Diseases Info Center
Common questions about chronic mast cell leukemia
Marcheggiani Muccioli GM (2024). [PMID: 38835476](https://pubmed.ncbi.nlm.nih.gov/38835476/). *Arthroscopy techniques*. [Clinical Trial Publication]
Meena A (2024). [PMID: 39539320](https://pubmed.ncbi.nlm.nih.gov/39539320/). *Indian journal of orthopaedics*. [Review / Meta-Analysis]