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systemic mastocytosis - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

systemic mastocytosis

MONDO:0016586

Also known as:Mast cell diseaseSMCD - systemic mast cell diseasesystemic tissue Mast cell disease

Find Clinical TrialsTrials

Overview

Systemic mastocytosis (SM) comprises a heterogeneous group of rare acquired and chronic hematological malignancies that are related to an abnormal proliferation of mast cells in tissue, including bone marrow, with or without skin involvement.

Clinical Trials10 registered · 5 recruiting

Diagnosis

Biomarker and diagnostic research for systemic mastocytosis has been reported in the published literature.

Prognosis

Estimated prevalence: 1-5 in 10,000 (Uncommon).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

10 clinical trials registered, 5 recruiting. Interventions under study include drug therapy and other interventions. Pipeline includes 5 PHASE2, 1 PHASE1. Research is sponsored by a mix of industry and academic institutions.

NCT ID	Title	Phase	Sponsor	Status
[NCT07255638](https://clinicaltrials.gov/study/NCT07255638)

Data assembled from 4 of 12 sources · Last updated Sep 18, 2026, 4:02 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:2467

GARD

Genetic and Rare Diseases Info Center

GARD:8616

Questions for Your Care Team

→Are any of the 10 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Research Type	Count	% of Total
Patient case studies	50	24%
Research summaries	49	23%
Disease patterns and progression	26	12%
Clinical study results	25	12%
Testing and diagnosis research	22	11%
Laboratory research	22	11%
Other research	8	4%
New treatment approaches	7	3%

systemic mastocytosis

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications