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indolent systemic mastocytosis (ISM) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

indolent systemic mastocytosis

MONDO:0020331

Also known as:ISMindolent systemic mastocytosis (morphologic abnormality)

Find Clinical TrialsTrials

Overview

Indolent systemic mastocytosis (ISM) is a benign form of systemic mastocytosis (SM) characterized by an abnormal proliferation of mast cells either only in bone marrow or in numerous tissues.

Clinical Trials6 registered · 3 recruiting

Diagnosis

Biomarker and diagnostic research for indolent systemic mastocytosis has been reported in the published literature.

Prognosis

Estimated prevalence: 1-5 in 10,000 (Uncommon).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

6 clinical trials registered, 3 recruiting. Interventions under study include drug therapy and other interventions. Pipeline includes 4 PHASE2. Research is primarily industry-sponsored.

NCT ID	Title	Phase	Sponsor	Status
[NCT03731260](https://clinicaltrials.gov/study/NCT03731260)

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 2:57 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:98848

GARD

Genetic and Rare Diseases Info Center

GARD:19595

Questions for Your Care Team

→Are any of the 6 active clinical trials a good fit for my situation?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Research Type	Count	% of Total
Research summaries	39	28%
Disease patterns and progression	27	19%
Testing and diagnosis research	22	16%
Clinical study results	22	16%
Patient case studies	13	9%
Laboratory research	11	8%
New treatment approaches	4	3%
Other research	3	2%

indolent systemic mastocytosis

Overview

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Subtypes

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Recent Publications