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Heart block that occurs on or before 28 days of life.
Features include always present findings: Atrioventricular block; and very common findings: Third degree atrioventricular block. 35 total HPO annotations.
Organ System | Phenotype Count | Example Features |
|---|---|---|
Heart and blood vessels | 14 | Myocardial fibrosis, Myocardial calcification, Atrial arrhythmia |
Biomarker and diagnostic research for congenital heart block has been reported in the published literature.
Phenotype severity distribution: 1 always present feature, 1 very common feature, 2 common features.
Estimated prevalence: Unknown (Unknown prevalence).
No clinical trials have been registered for congenital heart block.
78 publications have been identified in PubMed for congenital heart block. Research spans Case Report / Case Series (40%), Review / Meta-Analysis (26%), and Epidemiology / Natural History (17%).
Research Type | Count | % of Total |
|---|---|---|
Patient case studies | 31 | 40% |
Data assembled from 5 of 12 sources · Last updated Sep 19, 2026, 6:53 PM UTC
Online Mendelian Inheritance in Man
European rare disease database
Genetic and Rare Diseases Info Center
2 |
Exercise intolerance, Fatigue |
Skin | 1 | Excessive sweating (hyperhidrosis) |
Growth and development | 1 | Intrauterine growth retardation |
Pregnancy and birth | 1 | Hydrops fetalis |
Digestive system | 1 | Feeding difficulties in infancy |
Lungs and breathing | 1 | Pleural effusion |
20 |
26% |
Disease patterns and progression | 13 | 17% |
Other research | 5 | 6% |
Testing and diagnosis research | 4 | 5% |
Clinical study results | 4 | 5% |
Laboratory research | 1 | 1% |
Saleh ZF (2026). [PMID: 40930382](https://pubmed.ncbi.nlm.nih.gov/40930382/). *American journal of obstetrics and gynecology*. [Review / Meta-Analysis]
Carter EL (2026). [PMID: 41373094](https://pubmed.ncbi.nlm.nih.gov/41373094/). *Prenatal diagnosis*. [Epidemiology / Natural History]
Buzzell A (2026). [PMID: 41439852](https://pubmed.ncbi.nlm.nih.gov/41439852/). *Lupus*. [Review / Meta-Analysis]
Menting J (2026). [PMID: 41579125](https://pubmed.ncbi.nlm.nih.gov/41579125/). *JACC Case Rep*. [Case Report / Case Series]
Menchaca-Aguayo H (2026). [PMID: 41802920](https://pubmed.ncbi.nlm.nih.gov/41802920/). *Pediatr Dermatol*. [Case Report / Case Series]
Zhou SY (2026). [PMID: 41940214](https://pubmed.ncbi.nlm.nih.gov/41940214/). *Obstet Med*. [Review / Meta-Analysis]
Martin de Frémont G (2026). [PMID: 41564310](https://pubmed.ncbi.nlm.nih.gov/41564310/). *Rheumatology (Oxford)*. [Diagnostic / Biomarker]
Martin de Frémont G (2026). [PMID: 42059118](https://pubmed.ncbi.nlm.nih.gov/42059118/). *Ann Rheum Dis*. [Other]
Ahmed HF (2026). [PMID: 40641427](https://pubmed.ncbi.nlm.nih.gov/40641427/). *World J Pediatr Congenit Heart Surg*. [Clinical Trial Publication]
Perumalu K (2026). [PMID: 41717125](https://pubmed.ncbi.nlm.nih.gov/41717125/). *Eur Heart J Case Rep*. [Case Report / Case Series]
AI-curated news mentioning congenital heart block
Updated Sep 1, 2026
Recent research highlights the connection between neonatal lupus and congenital heart block, providing insights into the underlying mechanisms. This study may enhance understanding and management of these conditions.
A recent study highlights the risk of permanent heart block associated with pulsed-field ablation of the cavotricuspid isthmus. This finding underscores the need for careful patient selection and monitoring during this procedure.