Kisho

Kisho is an information platform, not a medical provider. Nothing on this site constitutes medical advice, diagnosis, or treatment recommendations. All content is aggregated from publicly available sources (including ClinicalTrials.gov, PubMed, FDA.gov, and Orphanet) and is provided for informational purposes only. Clinical trial eligibility, treatment decisions, and any health-related actions should always be discussed with a qualified healthcare professional. Kisho does not endorse any specific therapy, organization, or clinical trial. Terms of use · Privacy policy

congenital rubella syndrome (CRS) - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

congenital rubella syndrome

MONDO:0017361

Also known as:CRSRubella, Congenitalcongenital rubella

Overview

An infectious embryofetopathy that may present in an infant as a result of maternal infection and subsequent fetal infection with rubella virus. CRS can lead to deafness, cataract, and variety of other permanent manifestations including cardiac and neurological defects.

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Inner ear hearing loss (sensorineural hearing impairment), Cataract, Intrauterine growth retardation, and Abnormal speech pattern; and common findings: Abnormal cranial suture/fontanelle morphology, Microcephaly, Strabismus, and Glaucoma and others. 31 total HPO annotations.

Organ System	Phenotype Count	Example Features
Eyes	7	Strabismus, Glaucoma, Visual impairment

Diagnosis

Biomarker and diagnostic research for congenital rubella syndrome has been reported in the published literature.

Prognosis

Phenotype severity distribution: 4 very common features, 22 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for congenital rubella syndrome.

84 publications have been identified in PubMed for congenital rubella syndrome. Research spans Epidemiology / Natural History (43%), Case Report / Case Series (18%), and Review / Meta-Analysis (15%).

Research Type	Count	% of Total
Disease patterns and progression	36	43%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 11:56 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:290

GARD

Genetic and Rare Diseases Info Center

GARD:4744

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

← Back to All Diseases

Kisho

congenital rubella syndrome

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Notes from the Field: Congenital Rubella Syndrome — Florida, 2025

congenital rubella syndrome

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Notes from the Field: Congenital Rubella Syndrome — Florida, 2025