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fetal parvovirus syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

fetal parvovirus syndrome

MONDO:0017453

Also known as:Human parvovirus B19 caused infectious embryofetopathyHuman parvovirus B19 infectious embryofetopathyParvovirus antenatal infection

Overview

Foetal parvovirus syndrome is a foetopathy likely to occur when a pregnant woman is infected by parvovirus B19. In adults, the virus causes a butterfly erythema infectiosum (also called Fifth Disease; 'slapped cheek disease') and flu-like symptoms with symmetric polyarthralgias, which usually do not warrant prenatal diagnosis.

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Ascites, Hydrops fetalis, Low platelet count (thrombocytopenia), and Low red blood cell count (anemia); and sometimes findings: Abnormality of the eye, Abnormality of vision, Intrauterine growth retardation, and Thickened heart muscle (hypertrophic cardiomyopathy) and others.

Organ System	Phenotype Count	Example Features
Eyes	2	Abnormality of the eye, Abnormality of vision

Prognosis

Phenotype severity distribution: 4 very common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for fetal parvovirus syndrome.

10 publications have been identified in PubMed for fetal parvovirus syndrome. Research spans Case Report / Case Series (30%), Review / Meta-Analysis (20%), and Epidemiology / Natural History (20%).

Research Type	Count	% of Total
Patient case studies	3	30%

Data assembled from 4 of 12 sources · Last updated Sep 20, 2026, 11:13 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:295

GARD

Genetic and Rare Diseases Info Center

GARD:4236

Questions for Your Care Team

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Kisho

fetal parvovirus syndrome

Overview

Clinical Presentation

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

fetal parvovirus syndrome

Overview

Clinical Presentation

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications