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congenital herpes simplex virus infection - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

congenital herpes simplex virus infection

MONDO:0017381

Also known as:Simplexvirus caused infectious embryofetopathySimplexvirus infectious embryofetopathyantenatal herpes simplex virus infection

Overview

Congenital herpes virus infection is a group of anomalies that an infant may present as a result of maternal infection and subsequent fetal infection with herpes virus. This virus causes recurrent cutaneous infections in adults, often involving the lips or the genitalia. Herpes infections in other organs, such as the liver or central nervous system, are less frequent.

ResearchLimited published research (8 articles)

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include common findings: Intrauterine growth retardation and Premature birth; and sometimes findings: Microcephaly and Hydranencephaly.

Organ System	Phenotype Count	Example Features
Head and neck	1	Microcephaly
Growth and development

Diagnosis

Biomarker and diagnostic research for congenital herpes simplex virus infection has been reported in the published literature.

Prognosis

Phenotype severity distribution: 2 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for congenital herpes simplex virus infection.

8 publications have been identified in PubMed for congenital herpes simplex virus infection. Research spans Epidemiology / Natural History (50%), Diagnostic / Biomarker (13%), and Review / Meta-Analysis (13%).

Recent Publications

McCluskey JM (2026). [PMID: 38861626](https://pubmed.ncbi.nlm.nih.gov/38861626/). *Unknown Journal*. [Epidemiology / Natural History]
Pawlak-Zalewska WE (2026). [PMID: 41979577](https://pubmed.ncbi.nlm.nih.gov/41979577/). *Przegl Epidemiol*. [Review / Meta-Analysis]
Bettolini L (2025). [PMID: 40401852](https://pubmed.ncbi.nlm.nih.gov/40401852/). *Dermatology practical & conceptual*. [Diagnostic / Biomarker]
Klein JMA (2024). [PMID: 39430093](https://pubmed.ncbi.nlm.nih.gov/39430093/). *Ecancermedicalscience*. [Epidemiology / Natural History]
Vilibic-Cavlek T (2024). [PMID: 38920973](https://pubmed.ncbi.nlm.nih.gov/38920973/). *Antibodies (Basel, Switzerland)*. [Epidemiology / Natural History]

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 5:33 AM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:293

GARD

Genetic and Rare Diseases Info Center

GARD:18687

Questions for Your Care Team

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Kisho

congenital herpes simplex virus infection

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Latest News & Developments

Multifocal mucocutaneous herpes simplex virus type 1 infection temporally associated with seasonal influenza vaccination in a young adult without a known immunocompromising condition: A case report.

Primary vulvar extramammary Paget disease associated with herpes simplex virus infection: a rare case report.

A case of atypical orf virus infection of the hand in an immunocompromised patient.

congenital herpes simplex virus infection

Overview

Clinical Presentation

Diagnosis

Prognosis

Research Landscape

Recent Publications

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Latest News & Developments

Multifocal mucocutaneous herpes simplex virus type 1 infection temporally associated with seasonal influenza vaccination in a young adult without a known immunocompromising condition: A case report.

Primary vulvar extramammary Paget disease associated with herpes simplex virus infection: a rare case report.

A case of atypical orf virus infection of the hand in an immunocompromised patient.