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congenital varicella syndrome - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

congenital varicella syndrome

MONDO:0017372

Also known as:antenatal varicella virus infectionmother-to-child transmission of varicella syndromeVaricella embryopathy

Overview

Fetal varicella syndrome (CVS) is an acquired developmental anomaly syndrome characterized by skin, neurological, ocular, limbs and growth defects secondary to maternal Varicella-Zoster Virus (VZV) infection.

Clinical Presentation

Built from Human Phenotype Ontology (HPO) phenotype annotations and GeneReviews clinical descriptions. Features represent findings documented across known cases — not an exhaustive list of possible symptoms.

Features include very common findings: Atypical scarring of skin and Intrauterine growth retardation; and common findings: Microcephaly, Cataract, Microphthalmia, and Intellectual disability and others.

Organ System	Phenotype Count	Example Features
Brain and nerves	3	Intellectual disability, Global developmental delay, Cerebral cortical atrophy

Prognosis

Phenotype severity distribution: 2 very common features, 7 common features.

Estimated prevalence: Unknown (Unknown prevalence).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

No clinical trials have been registered for congenital varicella syndrome.

13 publications have been identified in PubMed for congenital varicella syndrome. Research spans Review / Meta-Analysis (46%), Epidemiology / Natural History (31%), and Case Report / Case Series (23%).

Research Type	Count	% of Total
Research summaries	6	46%

Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 5:27 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:291

GARD

Genetic and Rare Diseases Info Center

GARD:45

Questions for Your Care Team

→Are there specialists or centers of excellence for this condition in my area?
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Kisho

congenital varicella syndrome

Overview

Clinical Presentation

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Beyond the Rash: Simultaneous Bilateral Facial Nerve Palsy Following Childhood Varicella Infection.

Post Varicella lung fibrosis: a lingering scar of viral pneumonia.

CDC's Advisory Committee Recommends Changes in Varicella Vaccinations

congenital varicella syndrome

Overview

Clinical Presentation

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Explore clinical features

Recent Publications

Latest News & Developments

Beyond the Rash: Simultaneous Bilateral Facial Nerve Palsy Following Childhood Varicella Infection.

Post Varicella lung fibrosis: a lingering scar of viral pneumonia.

CDC's Advisory Committee Recommends Changes in Varicella Vaccinations