Cryptococcosis — NIH Grants & Funding

MONDO:0005724

Funding Landscape

Cryptococcosis has a robust NIH research funding landscape with 54 funded grants and $69.3M in total funding over the period.

54funded grants from NIH

Portfolio: $26.0MCumulative: $69.3M38 active16 completed49 PIs25 institutions

+12% YoY(FY2024 vs FY2025)

7 new grants started in the last 12 months.

By Research Theme

Basic Science

Translational

Clinical

Epi / Nat. History

Biomarker / Dx

Funding by Fiscal Year

NIH fiscal year (Oct–Sep)

$11.9M

FY22

$17.5M

FY23

$17.3M

FY24

$19.4M

FY25

$3.2M

FY26

By Funding Mechanism

R01

R21

ZIA

K22

F31

R15

Basic Science(34)

Basic ScienceZIACompleted

Pathogenic differences between Cryptococcus neoformans and C. gattii

Kwon-Chung, Kyung·NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

$939,657 (FY2025)

NIH RePORTER

Basic ScienceZIACompleted

Stress Management of Cryptococcal Pathogens

Kwon-Chung, Kyung·NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

$939,657 (FY2025)

NIH RePORTER

Basic ScienceZIACompleted

Molecular Pathobiology of Cryptococcus neoformans

Williamson, Peter·NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

$816,118 (FY2025)

NIH RePORTER

Basic ScienceR01Active

Solving the puzzle of beta-1,6-glucan in the cryptococcal cell wall

Doering, Tamara et al.·WASHINGTON UNIVERSITY·SAINT LOUIS, MO

$773,053 (FY2025)

NIH RePORTER

Basic ScienceR01Active

Sphingosine kinase and cryptococcal granuloma

Del Poeta, Maurizio·STATE UNIVERSITY NEW YORK STONY BROOK·STONY BROOK, NY

$772,778 (FY2026)

NIH RePORTER

Basic ScienceR01Active

Preclinical studies of a Cryptococcus vaccine for AIDS patients

Levitz, Stuart et al.·DUKE UNIVERSITY·DURHAM, NC

$769,284 (FY2025)

NIH RePORTER

Basic ScienceR01Active

Impact of Cryptococcus titan cells on pathogenesis

Nielsen, Kirsten·VIRGINIA POLYTECHNIC INST AND ST UNIV·BLACKSBURG, VA

$721,902 (FY2025)

NIH RePORTER

Basic ScienceR01Active

The role of inositol in Cryptococcus biology and pathogenesis

Xue, Chaoyang·RUTGERS BIOMEDICAL AND HEALTH SCIENCES·Newark, NJ

$674,556 (FY2025)

NIH RePORTER

Basic ScienceR01Active

Lipid-mediated fungal pathogenesis

Del Poeta, Maurizio·STATE UNIVERSITY NEW YORK STONY BROOK·STONY BROOK, NY

$659,883 (FY2025)

NIH RePORTER

Basic ScienceR01Active

Maturation, Germination, and Pathogenesis of Cryptococcus Spores

HULL, CHRISTINA·UNIVERSITY OF WISCONSIN-MADISON·MADISON, WI

$614,385 (FY2025)

NIH RePORTER

Translational(10)

TranslationalR01Active

Mechanisms of vaccine protection against AIDS-associated Cryptococcus infection

Rivera, Amariliz et al.·RUTGERS BIOMEDICAL AND HEALTH SCIENCES·Newark, NJ

$736,637 (FY2025)

NIH RePORTER

TranslationalR01Active

Exploiting antibody catalysis for treating Cryptococcosis

Casadevall, Arturo·JOHNS HOPKINS UNIVERSITY·BALTIMORE, MD

$725,763 (FY2025)

NIH RePORTER

TranslationalR01Active

Natural genomic variants that influence cryptococcal pathogenicity

Doering, Tamara·WASHINGTON UNIVERSITY·SAINT LOUIS, MO

$583,385 (FY2024)

NIH RePORTER

TranslationalR01Active

Cryptococcal vaccine development based on strong immunity induced by morphological strains

Lin, Xiaorong·UNIVERSITY OF GEORGIA·ATHENS, GA

$577,493 (FY2025)

NIH RePORTER

TranslationalR01Active

Role of phospholipids in antifungal drug resistance in Cryptococcus neoformans

Xue, Chaoyang·RUTGERS BIOMEDICAL AND HEALTH SCIENCES·Newark, NJ

$550,814 (FY2025)

NIH RePORTER

TranslationalR01Completed

Conjugate vaccines for prevention and treatment of cryptococcosis

Casadevall, Arturo·JOHNS HOPKINS UNIVERSITY·BALTIMORE, MD

$692,433 (FY2024)

NIH RePORTER

TranslationalR01Completed

Antibodies, B cells and resistance to human cryptococcosis

Pirofski, Liise-anne·ALBERT EINSTEIN COLLEGE OF MEDICINE·BRONX, NY

$532,469 (FY2024)

NIH RePORTER

TranslationalR21Completed

Interactions of Cryptococcus neoformans with mononuclear phagocytes in the brain

Shi, Meiqing·UNIV OF MARYLAND, COLLEGE PARK·COLLEGE PARK, MD

$231,190 (FY2024)

NIH RePORTER

TranslationalR21Completed

Develop and Assess mRNA Lipid Nanoparticle Vaccines Against Cryptococcosis

Lin, Xiaorong et al.·UNIVERSITY OF GEORGIA·ATHENS, GA

$217,673 (FY2024)

NIH RePORTER

TranslationalF30Completed

The adaptive host response to latent cryptococcosis

Ding, Minna·UNIVERSITY OF MINNESOTA·MINNEAPOLIS, MN

$19,687 (FY2025)

NIH RePORTER

Clinical(6)

ClinicalRF1Active

Understanding the causes of second episode cryptococcal meningitis to improve diagnosis and treatment

Bahr, Nathan et al.·UNIVERSITY OF MINNESOTA·MINNEAPOLIS, MN

$1,841,519 (FY2025)

NIH RePORTER

ClinicalZIACompleted

Translational Research: Host-Pathogen Interactions in Patient Fungal Diseases

Williamson, Peter·NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

$816,118 (FY2025)

NIH RePORTER

ClinicalU01Active

Enhanced Antifungal Therapy to Improve Survival in Early Disseminated Cryptococcal Infection

Rajasingham, Radha·UNIVERSITY OF MINNESOTA·MINNEAPOLIS, MN

$274,913 (FY2025)

NIH RePORTER

ClinicalR21Active

Late Neurological Sequelae after Cryptococcal Meningitis

Nsangi, Laura·INFECTIOUS DISEASES INSTITUTE·KAMPALA

$172,687 (FY2025)

NIH RePORTER

ClinicalUG3Completed

Encochleated Oral Amphotericin for HIV-related Cryptococcal Meningitis Trial: Phase 3 Trial

Boulware, David et al.·UNIVERSITY OF MINNESOTA·MINNEAPOLIS, MN

$2,145,116 (FY2023)

NIH RePORTER

ClinicalR21Completed

5-Lipoxygenase Inhibition as a Therapy to Prevent Cryptococcus-related IRIS

Wormley, Floyd·TEXAS CHRISTIAN UNIVERSITY·FORT WORTH, TX

$145,825 (FY2022)

NIH RePORTER

Epi / Nat. History(3)

Epi / Nat. HistoryR01Active

Using massive, multi-regional EHR data to estimate the impacts of environmental and other risk factors on fungal disease epidemiology in the U.S.

Hoffman, Mark et al.·UNIVERSITY OF MISSOURI KANSAS CITY·KANSAS CITY, MO

$783,681 (FY2025)

NIH RePORTER

Epi / Nat. HistoryR01Completed

Genomic Research Capacity Building for Cryptococcosis Translational Studies

Bazira, Joel et al.·UNIVERSITY OF MINNESOTA·MINNEAPOLIS, MN

$552,587 (FY2024)

NIH RePORTER

Epi / Nat. HistoryR21Completed

Population Structure and Clinical Impact of Multi-strain and Mixed-species Cryptococcal Infections

Magwene, Paul et al.·DUKE UNIVERSITY·DURHAM, NC

$201,250 (FY2024)

NIH RePORTER

Biomarker / Dx(1)

Biomarker / DxK23Active

Antibody Biomarkers of Cryptococcosis in Immunosuppressed Solid Organ Transplant Recipients

Yoon, Hyun Ah·ALBERT EINSTEIN COLLEGE OF MEDICINE·BRONX, NY

$199,584 (FY2025)

NIH RePORTER

Adjacent Research(6 grants)

These grants mention Cryptococcosis as part of broader research but are not primarily focused on this disease. They are not included in the funding totals above.

Other(6)

OtherR01Active

A subunit Cryptococcus vaccine

Levitz, Stuart·UNIV OF MASSACHUSETTS MED SCH WORCESTER·WORCESTER, MA

$619,839 (FY2025)

NIH RePORTER

OtherK24Active

Midcareer Mentoring for Clinical Research in HIV/AIDS-related cryptococcal and TB meningitis

Boulware, David·UNIVERSITY OF MINNESOTA·MINNEAPOLIS, MN

$215,860 (FY2025)

NIH RePORTER

OtherK01Active

Advancing Fungal Disease Epidemiology through Multilevel Modeling and Data Integration

Bustamante, Brittany·UNIVERSITY OF CALIFORNIA BERKELEY·BERKELEY, CA

$200,340 (FY2025)

NIH RePORTER

OtherR01Completed

Sphingosine-1-phosphate and cryptococcosis

Del Poeta, Maurizio·STATE UNIVERSITY NEW YORK STONY BROOK·STONY BROOK, NY

$498,277 (FY2022)

NIH RePORTER

OtherR01Completed

Synergy of Host Defense Mechanisms in the Lung

Casadevall, Arturo·JOHNS HOPKINS UNIVERSITY·BALTIMORE, MD

$409,375 (FY2023)

NIH RePORTER

OtherR41Completed

Therapeutic Agents Targeting Cryptococcal Infections

Wright, Dennis·QUERCUS MOLECULAR DESIGN, LLC·Farmington, CT

$297,725 (FY2024)

NIH RePORTER

Top Funded Institutions

UNIVERSITY OF MINNESOTA$4.9M

MN7 grantsBetancourt, Jovany, Bahr, Nathan +3

NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES$3.5M

4 grantsKwon-Chung, Kyung, Williamson, Peter

RUTGERS BIOMEDICAL AND HEALTH SCIENCES$2.1M

NJ4 grantsHargarten, Jessica, Xue, Chaoyang +1

DUKE UNIVERSITY$1.9M

NC4 grantsMagwene, Paul, Perfect, John +3

JOHNS HOPKINS UNIVERSITY$1.5M

MD3 grantsOrtiz, Sebastien, Casadevall, Arturo

STATE UNIVERSITY NEW YORK STONY BROOK$1.4M

NY2 grantsDel Poeta, Maurizio

UNIVERSITY OF GEORGIA$1.4M

GA4 grantsLin, Xiaorong, Meagher, Richard +1

WASHINGTON UNIVERSITY$1.4M

MO2 grantsDoering, Tamara, Wang, Tuo

UNIVERSITY OF FLORIDA$984K

FL2 grantsMartinez, Luis

UNIVERSITY OF MISSOURI KANSAS CITY$784K

MO1 grantHoffman, Mark, Remais, Justin +1

Top Principal Investigators

Meya, David$4.5M

UNIVERSITY OF MINNESOTA·3 grants

ClinicalEpi / Nat. History

Boulware, David$2.1M

UNIVERSITY OF MINNESOTA·1 grant

Clinical

Xue, Chaoyang$2.0M

RUTGERS BIOMEDICAL AND HEALTH SCIENCES·3 grants

TranslationalBasic Science

Kwon-Chung, Kyung$1.9M

NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES·2 grants

Basic Science

Bahr, Nathan$1.8M

UNIVERSITY OF MINNESOTA·1 grant

Clinical

Williamson, Peter$1.6M

NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES·2 grants

Basic ScienceClinical

Del Poeta, Maurizio$1.4M

STATE UNIVERSITY NEW YORK STONY BROOK·2 grants

Basic Science

Lin, Xiaorong$1.4M

UNIVERSITY OF GEORGIA·4 grants

TranslationalBasic Science

Casadevall, Arturo$1.4M

JOHNS HOPKINS UNIVERSITY·2 grants

Translational

Doering, Tamara$1.4M

WASHINGTON UNIVERSITY·2 grants

Basic ScienceTranslational

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