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Desmoplastic infantile astrocytoma/ganglioglioma are mixed neuronal-glial tumors representing a histological spectrum of the same tumor. They are usually supratentorially located, large, cystic masses with a peripheral solid component, characterized by prominent desmoplastic stroma and pleomorphic populations of neoplastic cells with either astrocytic or ganglionic differentiation and poorly differentiated cells in variable proportions. They usually present in the first 18 months of age with rapid head growth, bulging anterior fontanel and bone structures over the tumor, signs of raised intracranial pressure (headache, vomiting, papilledema), focal neurological signs and sometimes seizures.
No clinical trials have been registered for desmoplastic infantile astrocytoma/ganglioglioma.
5 publications have been identified in PubMed for desmoplastic infantile astrocytoma/ganglioglioma. Research spans Case Report / Case Series (40%), Review / Meta-Analysis (20%), and Basic Science / Preclinical (20%).
Kulac I (2026). [PMID: 41568174](https://pubmed.ncbi.nlm.nih.gov/41568174/). *Neurooncol Adv*. [Basic Science / Preclinical]
Karsonovich T (2026). [PMID: 30571036](https://pubmed.ncbi.nlm.nih.gov/30571036/). *Unknown Journal*. [Epidemiology / Natural History]
Lampros M (2025). [PMID: 41123688](https://pubmed.ncbi.nlm.nih.gov/41123688/). *Childs Nerv Syst*. [Review / Meta-Analysis]
Wang Q (2025). [PMID: 41450915](https://pubmed.ncbi.nlm.nih.gov/41450915/). *Front Oncol*. [Case Report / Case Series]
Jahani S (2024). [PMID: 39114838](https://pubmed.ncbi.nlm.nih.gov/39114838/). *Clin Case Rep*. [Case Report / Case Series]
Data assembled from 3 of 12 sources · Last updated Sep 20, 2026, 4:39 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
AI-curated news mentioning desmoplastic infantile astrocytoma/ganglioglioma
Updated Sep 9, 2026
A case study highlights suprasellar desmoplastic infantile ganglioglioma in a 7-month-old infant, emphasizing its rarity as a diagnostic consideration for suprasellar masses in infants. This research contributes to the understanding of this uncommon tumor type.