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A well differentiated, slow growing neuroepithelial neoplasm composed of neoplastic, mature ganglion cells and neoplastic glial cells. Some gangliogliomas show anaplastic features in their glial component and are considered to be WHO grade III. Rare cases of newly diagnosed gangliogliomas with grade IV (glioblastoma) changes in the glial component have also been reported. (Adapted from WHO)
Biomarker and diagnostic research for ganglioglioma has been reported in the published literature.
6 clinical trials registered, 1 recruiting. Interventions under study include procedural interventions, drug therapy, and other interventions. Pipeline includes 1 PHASE4, 1 PHASE2, 1 PHASE1. Research is sponsored by a mix of industry and academic institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT03152318](https://clinicaltrials.gov/study/NCT03152318) |
Data assembled from 4 of 12 sources · Last updated Sep 19, 2026, 1:04 PM UTC
European rare disease database
Genetic and Rare Diseases Info Center
A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2 |
PHASE1 |
Dana-Farber Cancer Institute |
UNKNOWN |
[NCT03975829](https://clinicaltrials.gov/study/NCT03975829) | Pediatric Long-Term Follow-up and Rollover Study | PHASE4 | Novartis Pharmaceuticals | ACTIVE_NOT_RECRUITING |
[NCT03919071](https://clinicaltrials.gov/study/NCT03919071) | Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma | PHASE2 | National Cancer Institute (NCI) | UNKNOWN |
[NCT04065776](https://clinicaltrials.gov/study/NCT04065776) | Evaluation of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma | NA | St. Jude Children's Research Hospital | UNKNOWN |
[NCT04648462](https://clinicaltrials.gov/study/NCT04648462) | Proton Therapy Research Infrastructure- ProTRAIT- Neuro-oncology | — | Maastricht Radiation Oncology | RECRUITING |
118 publications have been identified in PubMed for ganglioglioma. Kisho has analyzed 53 by research type. Research spans Review / Meta-Analysis (30%), Case Report / Case Series (30%), and Diagnostic / Biomarker (13%).
Research Type | Count | % of Total |
|---|---|---|
Research summaries | 16 | 30% |
Patient case studies | 16 | 30% |
Testing and diagnosis research | 7 | 13% |
Disease patterns and progression | 6 | 11% |
Clinical study results | 4 | 8% |
Laboratory research | 3 | 6% |
Other research | 1 | 2% |
Jaju A (2026). [PMID: 41274770](https://pubmed.ncbi.nlm.nih.gov/41274770/). *Neuroimaging Clin N Am*. [Review / Meta-Analysis]
Grubor I (2026). [PMID: 41518691](https://pubmed.ncbi.nlm.nih.gov/41518691/). *Seizure*. [Epidemiology / Natural History]
Pelissier L (2026). [PMID: 41591436](https://pubmed.ncbi.nlm.nih.gov/41591436/). *Pediatr Radiol*. [Review / Meta-Analysis]
Rameh V (2026). [PMID: 40962421](https://pubmed.ncbi.nlm.nih.gov/40962421/). *AJNR Am J Neuroradiol*. [Diagnostic / Biomarker]
Hauer J (2026). [PMID: 42080591](https://pubmed.ncbi.nlm.nih.gov/42080591/). *J Vet Intern Med*. [Case Report / Case Series]
Pereira BJA (2026). [PMID: 41721014](https://pubmed.ncbi.nlm.nih.gov/41721014/). *Childs Nerv Syst*. [Review / Meta-Analysis]
Matto C (2026). [PMID: 41612709](https://pubmed.ncbi.nlm.nih.gov/41612709/). *J Vet Diagn Invest*. [Case Report / Case Series]
Perfetto C (2025). [PMID: 40201310](https://pubmed.ncbi.nlm.nih.gov/40201310/). *Cancer Drug Resist*. [Basic Science / Preclinical]
Pereira BJA (2025). [PMID: 41099904](https://pubmed.ncbi.nlm.nih.gov/41099904/). *Neurosurg Rev*. [Review / Meta-Analysis]
Zahedi S (2025). [PMID: 40588233](https://pubmed.ncbi.nlm.nih.gov/40588233/). *Brain Pathol*. [Basic Science / Preclinical]