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diffuse alveolar hemorrhage - Clinical Profile, Genes & Research | Kisho | Kisho

Rare Disease

diffuse alveolar hemorrhage

MONDO:0019540

Also known as:diffuse alveolar haemorrhage (disease)diffuse alveolar hemorrhage (disease)

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Overview

A respiratory disorder characterized by diffuse bleeding into the alveolar spaces that originate from the pulmonary microvasculature, including the alveolar capillaries, arterioles and venules. Patients present with cough, dyspnea, chest pain, fever, anemia and hemoptysis.

TreatmentsNo approved treatments · 1 in pipeline

Clinical Trials2 registered · 2 recruiting

Diagnosis

Biomarker and diagnostic research for diffuse alveolar hemorrhage has been reported in the published literature.

Treatment

Compiled from FDA-approved drug records, orphan drug designations, and FDA Adverse Event Reporting System (FAERS) safety data. GeneReviews management guidance is included where available.

No approved treatments are currently available for diffuse alveolar hemorrhage. An additional 1 compound holds orphan drug designation.

Orphan Drug Designations

While no drugs are FDA-approved specifically for diffuse alveolar hemorrhage, some of the following designated compounds may be used off-label in clinical practice. Treatment decisions should be made in consultation with a specialist familiar with this condition.

The following drugs have received orphan drug designation from the FDA for diffuse alveolar hemorrhage. Orphan designation reflects regulatory interest and does not indicate approval for treatment.

Brand Name	Generic Name	Sponsor

Prognosis

Estimated prevalence: 1-9 in 100,000 (Uncommon).

Research Landscape

Sourced from ClinicalTrials.gov and PubMed. Publication types are classified using NLM-curated article metadata; research type breakdowns reflect the nature of published work for this disease.

2 clinical trials registered, 2 recruiting. Interventions under study include drug therapy and other interventions. Pipeline includes 1 PHASE1. Research is primarily sponsored by academic and government institutions.

252 publications have been identified in PubMed for diffuse alveolar hemorrhage. Kisho has analyzed 136 by research type. Research spans Case Report / Case Series (54%), Review / Meta-Analysis (18%), and Epidemiology / Natural History (11%).

Research Type	Count	% of Total
Patient case studies	73

Data assembled from 5 of 12 sources · Last updated Sep 20, 2026, 2:11 PM UTC

MONDOHPOClinicalTrials.govFDAPubMedHGNCClinVarClinGenGeneReviewsOrphanetOMIMRUSP

Medical References

External Resources

Orphanet

European rare disease database

Orphanet:90060

GARD

Genetic and Rare Diseases Info Center

GARD:19110

Questions for Your Care Team

→Are any of the 2 active clinical trials a good fit for my situation?
→What is the current development status of Recombinant coagulation factor VIIa, and when might it become available?
→Are there specialists or centers of excellence for this condition in my area?
→Is there a patient registry I should consider joining?

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Kisho

diffuse alveolar hemorrhage

Overview

Diagnosis

Treatment

Orphan Drug Designations

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications

Latest News & Developments

Two Cases of Diffuse Alveolar Haemorrhage Attributable to Human Metapneumovirus Infection: A Case Report.

Clinical, radiological and laboratory features and outcomes of diffuse alveolar hemorrhage.

CD20 monoclonal antibody‑rituximab for the treatment of diffuse alveolar hemorrhage in children (Review).

diffuse alveolar hemorrhage

Overview

Diagnosis

Treatment

Orphan Drug Designations

Prognosis

Research Landscape

Medical References

External Resources

Orphanet

GARD

Related Diseases

Questions for Your Care Team

Questions for Your Care Team

Clinical Trials

Recent Publications

Latest News & Developments

Two Cases of Diffuse Alveolar Haemorrhage Attributable to Human Metapneumovirus Infection: A Case Report.

Clinical, radiological and laboratory features and outcomes of diffuse alveolar hemorrhage.

CD20 monoclonal antibody‑rituximab for the treatment of diffuse alveolar hemorrhage in children (Review).