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A diffuse large B-cell lymphoma that is characterized by the expression of CD44, PKCbeta1, Cyclin D2, BCL-2, and IRF4/MUM1 genes.
Biomarker and diagnostic research for diffuse large B-cell lymphoma activated B-cell type has been reported in the published literature.
6 clinical trials registered, 2 recruiting. Interventions under study include drug therapy, procedural interventions, biologic therapy, and other interventions. Pipeline includes 1 PHASE3, 3 PHASE2, 1 PHASE1. Research is primarily sponsored by academic and government institutions.
NCT ID | Title | Phase | Sponsor | Status |
|---|---|---|---|---|
[NCT04512716](https://clinicaltrials.gov/study/NCT04512716) |
Data assembled from 3 of 12 sources · Last updated Sep 19, 2026, 2:52 PM UTC
Iomab-ACT: A Pilot Study of 131-I Apamistamab Followed by CD19-Targeted CAR T-Cell Therapy for Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia or Diffuse Large B-Cell Lymphoma |
EARLY_PHASE1 |
Memorial Sloan Kettering Cancer Center |
RECRUITING |
[NCT02443077](https://clinicaltrials.gov/study/NCT02443077) | Ibrutinib Before and After Stem Cell Transplant in Treating Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma | PHASE3 | National Cancer Institute (NCI) | UNKNOWN |
[NCT05755087](https://clinicaltrials.gov/study/NCT05755087) | Tegavivint for Treating Patients With Relapsed or Refractory Large B-Cell Lymphoma | PHASE1 | Lapo Alinari | UNKNOWN |
[NCT06834373](https://clinicaltrials.gov/study/NCT06834373) | Golcadomide and Rituximab as Bridging Therapy for Relapsed or Refractory Aggressive B-cell Non-Hodgkin Lymphoma Before CAR T-cell Therapy | PHASE2 | Mayo Clinic | RECRUITING |
[NCT04799275](https://clinicaltrials.gov/study/NCT04799275) | Testing CC-486 (Oral Azacitidine) Plus the Standard Drug Therapy in Patients 75 Years or Older With Newly Diagnosed Diffuse Large B Cell Lymphoma | PHASE2 | National Cancer Institute (NCI) | UNKNOWN |
130 publications have been identified in PubMed for diffuse large B-cell lymphoma activated B-cell type. Kisho has analyzed 28 by research type. Research spans Basic Science / Preclinical (39%), Review / Meta-Analysis (18%), and Case Report / Case Series (11%).
Research Type | Count | % of Total |
|---|---|---|
Laboratory research | 11 | 39% |
Research summaries | 5 | 18% |
Patient case studies | 3 | 11% |
New treatment approaches | 3 | 11% |
Testing and diagnosis research | 2 | 7% |
Clinical study results | 2 | 7% |
Other research | 1 | 4% |
Disease patterns and progression | 1 | 4% |
Mestermann K (2025). [PMID: 39589646](https://pubmed.ncbi.nlm.nih.gov/39589646/). *BioDrugs*. [Review / Meta-Analysis]
Mei H (2025). [PMID: 40830921](https://pubmed.ncbi.nlm.nih.gov/40830921/). *Chin Med J (Engl)*. [Basic Science / Preclinical]
Tumuluru S (2025). [PMID: 39869833](https://pubmed.ncbi.nlm.nih.gov/39869833/). *Blood*. [Basic Science / Preclinical]
Pirosa MC (2025). [PMID: 40359477](https://pubmed.ncbi.nlm.nih.gov/40359477/). *Blood*. [Basic Science / Preclinical]
Kang H (2025). [PMID: 40231473](https://pubmed.ncbi.nlm.nih.gov/40231473/). *J Clin Invest*. [Basic Science / Preclinical]
Xiang QY (2025). [PMID: 40735318](https://pubmed.ncbi.nlm.nih.gov/40735318/). *Front Immunol*. [Other]
Ren C (2025). [PMID: 40314093](https://pubmed.ncbi.nlm.nih.gov/40314093/). *Int J Oncol*. [Review / Meta-Analysis]
Own SA (2025). [PMID: 40437466](https://pubmed.ncbi.nlm.nih.gov/40437466/). *BMC Cancer*. [Gene Therapy / Novel Therapeutics]
Al Shueili B (2025). [PMID: 39787145](https://pubmed.ncbi.nlm.nih.gov/39787145/). *PLoS One*. [Basic Science / Preclinical]
Andreadis C (2025). [PMID: 40632607](https://pubmed.ncbi.nlm.nih.gov/40632607/). *Leuk Lymphoma*. [Clinical Trial Publication]